I hereby declare that I have created this work completely on my own and used no other sources or tools than the ones listed, and that I have marked any citations accordingly. Hiermit versichere ich, dass ich die vorliegende Arbeit selbständig verfasst und keine anderen als die angegebenen Quellen und Hilfsmittel benutzt sowie Zitate kenntlich gemacht habe.

Modern stem cell studies now typically use a variety of different high-throughput techniques to deconstruct the molecular basis of cell-fate specification. Nevertheless, individual studies inevitably only focus on one chosen aspect of stem cell self-renewal, fate specification, or reprogramming

, inflammation and other diseases. In this paper, we focus on the NFκB pathway and construct a crosstalk model of the HMGB1-p53-NFκB-Ras-Rb network to investigate how these couplings influence proliferation and apoptosis (programmed cell death) of cancer cells. We first built a single-cell model of the HMGB1

Synovial sarcoma is a relatively rare high-grade soft tissue sarcoma that often develops in the limbs of young people and induces the lung and the lymph node metastasis resulting in poor prognosis. In patients with synovial sarcoma, specific chromosomal translocation of t(X; 18) (p11.2;q11

m]]l]]s¶D]]¿÷mB]iv]b]oD]m¶¨]iv]§]iv]r]j]t¿rv]]irj]]t]]m] / | ap]]r¿]ÎNy]s¶D]]mb¶r]ix} Û]Ix]]rd]mb]} p—N]t]o%ism] in]ty]m] / || Û]Is]¡uÎc]rN]]riv]nd]p]*N]m]st¶ I always bow to Śri ̄ Śāradāmbā, the limitless ocean of the nectar of compassion, who bears a rosary, a vessel of nectar, the symbol

I would like to thank Prof. Dr. Torsten Braun, head of the Computer Network and Distributed Systems group (RVS), for supervising this work and for his insightful advises. Prof. Dr. Torsten Braun encouraged and motivated me to publish my research results and he provided me the opportunity to present

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Abstract. We present a computational modeling approach to study fusion of multicellular aggregate systems in a novel scaffold-less biofabrication process, known as “bioprinting”. In this novel technology, live multicellular aggregates are used as fundamental building blocks to make tissues

Abstract. The Stellar Observations Network Group (SONG) has obtained full funding for the design, construction and implementation of a prototype telescope and instrumentation package for the first network node. We describe the layout of such a node and its instrumentation and expected performance

on differential network structures. We propose a novel method for efficiently exploiting network structure information in the comparison be-tween any graphs, and validate results in non-small cell lung cancer. We introduce the notion of differential graphlet community to detect deregulated subgraphs between any