Results 1 - 10 of 138

METHODOLOGY ARTICLE Open Access Construction of a computable cell proliferation network focused on non-diseased lung cells

by Jurjen W Westra, Walter K Schlage, Brian P Frushour, Stephan Gebel, Natalie L Catlett, Wanjiang Han, Sean F Eddy, Arnd Hengstermann, Andrea L Matthews, Carole Mathis, Rosemarie B Lichtner, Carine Poussin, Marja Talikka, Emilija Veljkovic, Aaron A Van Hooser, Benjamin Wong, Michael J Maria, Manuel C Peitsch, Renee Deehan, Julia Hoeng
"... Background: Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to apply to the analysis of systems biology data (transcriptomics, proteomics/phosphoproteomics, metabolomics, etc.). Ideally, these n ..."
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systems-level assessment of the biological impact of perturbations on non-diseased mammalian lung cells, we constructed a lung-focused network for cell proliferation. The network encompasses diverse biological areas that lead to the regulation of normal lung cell proliferation (Cell Cycle, Growth Factors

Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset

by Vincenzo Belcastro, Carine Poussin, Stephan Gebel, Carole Mathis, Walter K. Schlage, Rosemarie B. Lichtner, Sibille Quadt-humme, Ra Wagner, Julia Hoeng, Manuel C. Peitsch - Bioinf. Biol. Insights , 2013
"... This is an open access article published under the Creative Commons CC-BY-NC 3.0 license. ..."
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This is an open access article published under the Creative Commons CC-BY-NC 3.0 license.

Materials for an exploratory theory of the network society.

by Manuel Castells , Anthony Giddens , Alain Touraine , Anthony Smith , Benjamin Barber , Peter Hall , Roger-Pol Droit , Sophie Watson , Frank Webster , Krishan Kumar , David Lyon , Craig Calhoun , Jeffrey Henderson , Ramon Ramos , Jose E Rodrigues-Ibanez , Jose F Tezanos , Mary Kaldor , Stephen Jones , Christopher Freeman - The British Journal of Sociology , 2000
"... ABSTRACT This article aims at proposing some elements for a grounded theor y of the network society. The network society is the social structure characteristic of the Information Age, as tentatively identi ed by empirical, cross-cultural investigation. It permeates most societies in the world, in v ..."
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witnessing a proliferation of in uential, resourceful non-governmental organizations that interact with governments, and multinational political institutions. Thus, overall the new state is not any longer a nation-state. The state in the information age is a network state, a state made out of a complex web

Constructing module maps for integrated analysis of heterogeneous biological networks

by David Amar, Ron Shamir - Nucleic Acids Res
"... Improved methods for integrated analysis of heterogeneous large-scale omic data are direly needed. Here, we take a network-based approach to this challenge. Given two networks, representing different types of gene interactions, we construct a map of linked modules, where modules are genes strongly c ..."
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transcriptomes of non–small-cell lung cancer patients, we analyze networks of global co-expression and disease-dependent differential co-expression and identify a sharp drop in correlation between two modules of immune activation processes, with possible microRNA control. Our study demonstrates that module maps

Computational and experimental approaches for modeling gene regulatory networks

by J. Goutsias, N. H. Lee - Curr. Pharm. Design
"... Abstract: To understand most cellular processes, one must understand how genetic information is processed. A formidable challenge is the dissection of gene regulatory networks to delineate how eukaryotic cells coordinate and govern patterns of gene expression that ultimately lead to a phenotype. In ..."
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Abstract: To understand most cellular processes, one must understand how genetic information is processed. A formidable challenge is the dissection of gene regulatory networks to delineate how eukaryotic cells coordinate and govern patterns of gene expression that ultimately lead to a phenotype

unknown title

by Ida O
"... 5 nited ..."
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Abstract not found

Next-generation synthetic gene networks.

by Timothy K Lu - Nat. Biotechnol. , 2009
"... Synthetic gene networks: what have we learned and what do we need? The engineering of mechanical, electrical and chemical systems is enabled by well-established frameworks for handling complexity, reliable means of probing and manipulating system states and the use of testing platforms-tools that a ..."
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, synthetic biologists are often fundamentally limited by a dearth of interoperable and modular biological parts, predictive computational modeling capabilities, reliable means of characterizing information flow through engineered gene networks and test platforms for rapidly designing and constructing

Cross-talk between apoptosis and autophagy in lung epithelial cell death

by Jincheng Yang , Hyung-Geun Moon , Sukrutha Chettimada , Yang Jin
"... Abstract: As an essential organ for gas exchange, the lungs are constantly exposed to the external environment and are simulated by toxicants and pathogens. The integrity of lung epithelium and epithelial cells is crucial for fulfilling the physiological functions of the lung. The homeostasis of lu ..."
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of lung epithelial cells is maintained by a complex network by which survival and death are tightly regulated. Upon noxious stimulation, lung epithelium attempts to maintain its normal structure and function. Savage of injured cells and clearance of unsalvageable dying cells or unwanted proliferated cells

A synchronized quorum of genetic clocks

by Tal Danino, Octavio Mondragón-palomino, Lev Tsimring, Jeff Hasty - Nature , 2010
"... The engineering of genetic circuits with predictive functionality in living cells represents a defining focus of the expanding field of synthetic biology. This focus was elegantly set in motion a decade ago with the design and construction of a genetic toggle switch and an oscillator, with subsequen ..."
Abstract - Cited by 51 (5 self) - Add to MetaCart
The engineering of genetic circuits with predictive functionality in living cells represents a defining focus of the expanding field of synthetic biology. This focus was elegantly set in motion a decade ago with the design and construction of a genetic toggle switch and an oscillator

Research Article Identification of Lung-Cancer-Related Genes with the Shortest Path Approach in a Protein-Protein Interaction Network

by Xiang-yin Kong, Yu-dong Cai
"... Copyright © 2013 Bi-Qing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lung cancer is one of the leading causes of cancer ..."
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of cancer mortality worldwide. The main types of lung cancer are small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). In this work, a computational method was proposed for identifying lung-cancer-related genes with a shortest path approach in a protein-protein interaction (PPI) network
Results 1 - 10 of 138