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Combinatorial Clustering of Residue Position Subsets Predicts Inhibitor Affinity across the Human Kinome

by Drew H. Bryant, Mark Moll, Paul W. Finn, Lydia E. Kavraki , 2012
"... The protein kinases are a large family of enzymes that play fundamental roles in propagating signals within the cell. Because of the high degree of binding site similarity shared among protein kinases, designing drug compounds with high specificity among the kinases has proven difficult. However, co ..."
Abstract - Cited by 4 (2 self) - Add to MetaCart
, computational approaches to comparing the 3-dimensional geometry and physicochemical properties of key binding site residue positions have been shown to be informative of inhibitor selectivity. The Combinatorial Clustering Of Residue Position Subsets (CCORPS) method, introduced here, provides a semi

Structure-Guided Selection of Specificity Determining Positions in the

by Human Kinome, Mark Moll, Paul W. Finn, Lydia E. Kavraki
"... Abstract—It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. This is also the case for inhibitors of many other protein families. A better understanding of binding selectivity would enhance the design of drugs that target only a subfamily, thereby minim ..."
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of certain inhibitors is achieved, which is useful for lead optimization. In addition, the algorithm can also be used to predict binding affinities for structures whose affinity for a given inhibitor is unknown. The algorithm’s performance is demonstrated using an extensive dataset for the human kinome

Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic

by PhD Andrew B West
"... A B S T R AC T : The burden that Parkinson's disease (PD) exacts on the population continues to increase year after year. Though refinement of symptomatic treatments continues at a reasonable pace, no accepted therapies are available to slow or prevent disease progression. The leucine-rich rep ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
are made for predictive preclinical modeling and successful first-in-human trials. The upcoming tenth anniversary of the discovery of mutations in the leucine-rich repeat kinase 2 (LRRK2) gene in Parkinson's disease (PD) highlights numerous achievements in discovery and innovation Optimism also

synthase and

by Laura Strittmatter, Yang Li, Nathan J. Nakatsuka, Sarah E. Calvo, Zenon Grabarek, Vamsi K. Mootha , 2013
"... is a polymorphic human enzyme with malate ..."
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is a polymorphic human enzyme with malate

unknown title

by Laura Strittmatter, Yang Li, Nathan Nakatsuka, Sarah Calvo
"... CLYBL is a polymorphic human enzyme with malate synthase and -methylmalate synthase activity ..."
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CLYBL is a polymorphic human enzyme with malate synthase and -methylmalate synthase activity

Scenario Generation and Reduction for Long-term and Short-term Power System Generation Planning under Uncertainties

by Yonghan Feng, James D. Mccalley, William Q. Meeker, Jo Min, Lizhi Wang
"... ii ..."
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Abstract not found

TO CODE OR NOT TO CODE

by Présentée À La, Faculté Informatique, Et Communications, Section Des, Systèmes De Communication, Du Grade, De Docteur, Ès Sciences, Prof M. Vetterli, Prof B. Rimoldi, Prof R. Gallager, Prof A. Lapidoth, Prof J. Massey, Prof E. Telatar, Prof S. Verdú, Michael Gastpar, Amos Lapidoth, Jim Ma , 2002
"... de nationalité suisse et originaire de Zurich (ZH) et Lucerne (LU) acceptée sur proposition du jury: ..."
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de nationalité suisse et originaire de Zurich (ZH) et Lucerne (LU) acceptée sur proposition du jury:
Results 1 - 7 of 7
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