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Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environmental Health Perspectives Supplements 107
, 1999
"... During the last three decades, the impact of chemical pollution has focused almost exclusively on the conventional "priority " pollutants, especially those acutely toxic/carcinogenic pesticides and industrial intermediates displaying persistence in the environment. This spectrum of chemica ..."
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Cited by 108 (1 self)
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During the last three decades, the impact of chemical pollution has focused almost exclusively on the conventional "priority " pollutants, especially those acutely toxic/carcinogenic pesticides and industrial intermediates displaying persistence in the environment. This spectrum of chemicals, however, is only one piece of the larger puzzle in "holistic " risk assessment. Another diverse group of bioactive chemicals receiving comparatively little attention as potential environmental pollutants includes the pharmaceuticals and active ingredients in personal care products (in this review collectively termed PPCPs), both human and veterinary, including not just prescription drugs and biologics, but also diagnostic agents, "nutraceuticals, " fragrances, sun-screen agents, and numerous others. These compounds and their bioactive metabolites can be continually introduced to the aquatic environment as complex mixtures via a number of routes but primarily by both untreated and treated sewage. Aquatic pollution is particularly troublesome because aquatic organisms are captive to continual life-cycle, multigenerational exposure. The possibility for continual but undetectable or unnoticed effects on aquatic organisms is particularly worrisome because effects could accumulate so slowly that major change goes undetected until the cumulative level of these effects finally cascades to irreversible change-change that would
Anisotropic Acquisition and Analysis for Diffusion Tensor Magnetic Resonance Imaging
, 2006
"... Diffusion tensor magnetic resonance imaging (DT-MRI) is a non-invasive imaging method for assessing the characteristics and organization of tissue microstructure. The diffusion tensor provides information about the magnitude, anisotropy, and orientation of water diffusion in biological tissues. In b ..."
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Diffusion tensor magnetic resonance imaging (DT-MRI) is a non-invasive imaging method for assessing the characteristics and organization of tissue microstructure. The diffusion tensor provides information about the magnitude, anisotropy, and orientation of water diffusion in biological tissues
Mathematical Methods for Diffusion MRI Processing
, 2008
"... In this article, we review recent mathematical models and computational methods for the processing of diffusion Magnetic Resonance Images, including state-of-the-art reconstruction of diffusion models, cerebral white matter connectivity analysis, and segmentation techniques. We focus on Diffusion Te ..."
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Cited by 15 (2 self)
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In this article, we review recent mathematical models and computational methods for the processing of diffusion Magnetic Resonance Images, including state-of-the-art reconstruction of diffusion models, cerebral white matter connectivity analysis, and segmentation techniques. We focus on Diffusion Tensor Images (DTI) and Q-Ball Images (QBI).
D38 Action Metal Based System for Molecular Imaging Applications.
"... Molecular MRI of mouse atherosclerosis ..."
RESEARCH Open Access
"... Alterations of local spontaneous brain activity and connectivity in adults with high-functioning the right FG and pMTG, in the form of co-occurrence of spontaneous brain activity level and local connectivity, ..."
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Alterations of local spontaneous brain activity and connectivity in adults with high-functioning the right FG and pMTG, in the form of co-occurrence of spontaneous brain activity level and local connectivity,
DIFFUSION MRI Preface
, 2008
"... Over the last decade interest in diffusion MRI has exploded. The technique provides a unique insight into the microstructure of living tissue and enables in-vivo connectivity mapping of the brain. Tractography and connectivity mapping give fundamental new insights in neuroscience and neuroanatomy. F ..."
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Over the last decade interest in diffusion MRI has exploded. The technique provides a unique insight into the microstructure of living tissue and enables in-vivo connectivity mapping of the brain. Tractography and connectivity mapping give fundamental new insights in neuroscience and neuroanatomy
ANISOTROPIC POLARIZED LIGHT SCATTER AND MOLECULAR FACTOR COMPUTING IN PHARMACEUTICAL CLEANING VALIDATION AND BIOMEDICAL SPECTROSCOPY
"... Spectroscopy and other optical methods can often be employed with limited or no sample preparation, making them well suited for in situ and in vivo analysis. This dissertation focuses on the use of a near-infrared spectroscopy (NIRS) and polarized light scatter for two such applications: the assessm ..."
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molecular factor computing (MFC), was developed for differentiating cholesterol, collagen and elastin
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