www.elsevier.com/locate/patcog Though most approaches to protein comparison are based on their structure, several studies produced evidence of a strict correlation between the surface characteristics of proteins and the way they interact. Surface-based techniques for protein comparison typically

Cluster analysis is the automated search for groups of related observations in a data set. Most clustering done in practice is based largely on heuristic but intuitively reasonable procedures and most clustering methods available in commercial software are also of this type. However

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in the analysis of gene expression data is the detection of groups of genes that manifest similar expression patterns. The corresponding algorithmic problem is to cluster multi-condition gene expression patterns. In this paper we describe a novel clustering algorithm that was developed for analysis of gene

Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam (22.0) contains 9318 protein families. Pfam is now based not only on the UniProtKB sequence database, but also on NCBI Gen

The modern science of networks has brought significant advances to our understanding of complex systems. One of the most relevant features of graphs representing real systems is community structure, or clustering, i. e. the organization of vertices in clusters, with many edges joining vertices

This paper provides a comprehensive survey of the technical achievements in the research area of image retrieval, especially content-based image retrieval, an area that has been so active and prosperous in the past few years. The survey includes 100+ papers covering the research aspects of image feature representation and extraction, multidimensional indexing, and system design, three of the fundamental bases of content-based image retrieval. Furthermore, based on the state-of-the-art technology available now and the demand from real-world applications, open research issues are identified and future promising research directions are suggested. C ○ 1999 Academic Press 1.

A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised. For this purpose, a hydropathy scale has been composed wherein the hydrophilic and hydrophobic properties of each of the 20 amino acid side

Motivation: Homology models of proteins are of great interest for planning and analyzing biological experiments when no experimental three-dimensional structures are available. Building homology models requires specialized programs and up-to-date sequence and structural databases. Integrating all

of the classification show definite trends in the evolving registration techniques, which will be discussed. At this moment, the bulk of interesting intrinsic methods is either based on segmented points or surfaces, or on techniques endeavoring to use the full information content of the images involved. Keywords