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Long-Time Simulation of Calcium Waves in a Heart Cell to Study the Effects of Calcium Release Flux Density and of Coefficients in the Pump and Leak Mechanisms on Self-Organizing Wave Behavior

by Zana Coulibaly, Michael Muscedere, Matthias K. Gobbert, Bradford E. Peercy
"... Spontaneous calcium sparks can lead to propagation of a self-initiated calcium wave under certain conditions in a heart cell. A model for diffusion waves of calcium ions in a heart cell is given by a system of coupled, time-dependent reaction-diffusion equations. The key term of the model quantifies ..."
Abstract - Cited by 1 (1 self) - Add to MetaCart
quantifies the release of calcium at the calcium release units by a flux density. The model also includes pump and leak mechanisms that model the extruding and entering of calcium throughout the cell, respectively. Previous simulations for this model with extreme values of the flux density demonstrate

Calciuminduced calcium release in smooth muscle: loose coupling between the action potential and calcium

by M. L. Collier, G. Ji, Y. -x. Wang, M. I. Kotlikoff , 2000
"... abstract Calcium-induced calcium release (CICR) has been observed in cardiac myocytes as elementary calcium release events (calcium sparks) associated with the opening of L-type Ca 2 � channels. In heart cells, a tight coupling between the gating of single L-type Ca 2 � channels and ryanodine recept ..."
Abstract - Cited by 14 (4 self) - Add to MetaCart
abstract Calcium-induced calcium release (CICR) has been observed in cardiac myocytes as elementary calcium release events (calcium sparks) associated with the opening of L-type Ca 2 � channels. In heart cells, a tight coupling between the gating of single L-type Ca 2 � channels and ryanodine

The Statistics of Calcium-Mediated Focal Excitations on a One-Dimensional Cable

by Wei Chen , Mesfin Asfaw , Yohannes Shiferaw
"... ABSTRACT It is well known that various cardiac arrhythmias are initiated by an ill-timed excitation that originates from a focal region of the heart. However, up to now, it is not known what governs the timing, location, and morphology of these focal excitations. Recent studies have shown that thes ..."
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tissue. This model accounts for the stochastic nature of spontaneous Ca release on a one-dimensional cable of cardiac cells. Using this model, we show that the timing of focal excitations is equivalent to a first passage time problem in a spatially extended system. In particular, we find that for a short

i A TRANSIENT COMPUTATIONAL FLUID DYNAMIC STUDY OF A LABORATORY-SCALE FLUORINE

by Ryno Pretorius, Supervisor Prof, P. L. Crouse, Electrolysis Cell
"... Fluorine gas is produced industrially by electrolysing hydrogen fluoride in a potassium acid fluoride electrolyte. Fluorine is produced at the carbon anode, while hydrogen is produced at the mild-steel cathode. The fluorine produced has a wide range of uses, most notably in the nuclear industry wher ..."
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where it is used to separate 235U and 238U. The South African Nuclear Energy Corporation (Necsa) is a producer of fluorine and requested an investigation into the hydrodynamics of their electrolysis cells as part of a larger national initiative to beneficiate more of South Africa’s large fluorspar

DOI: 10.1140/epjst/e2012-01529-y THE EUROPEAN PHYSICAL JOURNAL SPECIAL TOPICS Review Active Brownian Particles From Individual to Collective Stochastic Dynamics

by P. Romanczuk, W. Ebeling, B. Lindner , 2012
"... Abstract. We review theoretical models of individual motility as well as collective dynamics and pattern formation of active particles. We focus on simple models of active dynamics with a particular emphasis on nonlinear and stochastic dynamics of such self-propelled entities in the framework of sta ..."
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Abstract. We review theoretical models of individual motility as well as collective dynamics and pattern formation of active particles. We focus on simple models of active dynamics with a particular emphasis on nonlinear and stochastic dynamics of such self-propelled entities in the framework

SYNTHESIS OF LEUKOTRIENE C AND OTHER ARACHIDONIC ACID METABOLITES BY MOUSE PULMONARY MACROPHAGES*

by Be Carol, A. Rouzer, William A. Scott, Anne L. Hamill, Ano Zanvil, A. Cohn
"... Recent work from this laboratory (1, 2) has demonstrated that mouse resident peritoneal macrophages release the slow-reacting substance (SRS), 1 leukotriene C [5(S)-hydroxy-6(R)-glutathionyl-7,9,11,14-eicosatetraenoic acid; LTC] in response to a phagocytic stimulus. No data are as yet available conc ..."
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ventricle of the heart until the lung tissue was uniformly white. The trachea was then cannulated, and the lungs were washed five times with 1 ml of buffered saline containing EDTA at 37°C. These washes, which contained PAM, were combined and placed on ice. For culture, the cells were washed once

unknown title

by unknown authors
"... Sympathetic stimulation of the heart through β-adrenergic receptors is a prominent extrinsic control mechanism of contractile force and cardiac function.1,2 Binding of (nor)epi-nephrine to β-adrenergic type 1 receptors leads to generation of cAMP that activates protein kinase A (PKA), leading to pho ..."
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,2 In ventricular myocytes, the inotropic effect is mainly at-tributed to PKA-mediated increase in L-type Ca2+ channel– mediated Ca2+ entry and subsequent Ca2+-induced Ca2+ release (CICR), resulting in a larger Ca2+ transient and stronger con-traction.1,2 Furthermore, phosphorylation of phospholamban by PKA

JEAN-LUC GENNISSON

by Universite Paris, Vi Pierre, Et Marie Curie, Espci Paristech, Habilitation A Diriger Des, Dr. Damien, Pr. Michel, Dr. Mickaël, Tanter Examinateur, Jean-luc Gennisson, H. D. R. Université, Paris Vi
"... RECHERCHES Elastographie par ondes de cisaillement ..."
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RECHERCHES Elastographie par ondes de cisaillement

BDRS PRICE DESCRIPTOR,

by unknown authors
"... This report focuses on the evidence about the health.consequences of smoking for women, and is intended to serve.the public health and medical communities as 'a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including tre ..."
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This report focuses on the evidence about the health.consequences of smoking for women, and is intended to serve.the public health and medical communities as 'a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including

To eat or to sleep? Orexin in the regulation of feeding and wakefulness,”

by Jon T Willie , Richard M Chemelli , Christopher M Sinton , Masashi Yanagisawa - Annual Review of Neuroscience, , 2001
"... Key Words appetite, metabolism, arousal, narcolepsy, lateral hypothalamus s Abstract Orexin-A and orexin-B are neuropeptides originally identified as endogenous ligands for two orphan G-protein-coupled receptors. Orexin neuropeptides (also known as hypocretins) are produced by a small group of neur ..."
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and orexin-B while screening high-resolution highperformance liquid chromatography fractions from brain extracts for stimulation of signal transduction in cell lines expressing orphan G-protein-coupled receptors (GPCRs) A single gene composed of two exons and an intervening intron encodes the orexin
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