Results 1 - 10 of 33

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

by Estela Jacinto , Robbie Loewith , Anja Schmidt , Shuo Lin , Markus A Rüegg , Alan Hall , Michael N Hall - Nature Cell Biol. , 2004
"... The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein complexes: TORC1 and TORC2. A mammalian counterpart of TORC1 (mTORC1) has been described, but it is not known ..."
Abstract - Cited by 109 (3 self) - Add to MetaCart
genomes revealed fragments of a probable vertebrate homologue of the TORC2-specific protein AVO3. Mammalian AVO3 (mAVO3) was cloned from mouse C2C12 cDNA and sequenced, revealing a putative protein of 1,708 amino acids that shares about 25% identity with S. cerevisiae AVO3. Although there are no obvious

The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota

by Lanming Chen, Kim Brügger, Marie Skovgaard, Peter Redder, Qunxin She, Elfar Torarinsson, Bo Greve, Mariana Awayez, Arne Zibat, Hans-peter Klenk, Roger A. Garrett - J. Bacteriol , 2005
"... Sulfolobus acidocaldarius is an aerobic thermoacidophilic crenarchaeon which grows optimally at 80°C and pH 2 in terrestrial solfataric springs. Here, we describe the genome sequence of strain DSM639, which has been used for many seminal studies on archaeal and crenarchaeal biology. The circular gen ..."
Abstract - Cited by 57 (6 self) - Add to MetaCart
identified protein-coding genes for Sulfolobus, are incorporated into a public Sulfolobus database which can be

Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1

by Yasukazu Nakamura, Takakazu Kaneko, Shusei Sato, Masahiko Ikeuchi, Hiroshi Katoh, Shigemi Sasamoto, Akiko Watanabe, Mayumi Iriguchi, Kumiko Kawashima, Takaharu Kimura, Yoshie Kishida, Chiaki Kiyokawa, Mitsuyo Kohara, Midori Matsumoto, Ai Matsuno, Naomi Nakazaki, Sayaka Shimpo, Masako Sugimoto, Chie Takeuchi, Manabu Yamada, Satoshi Tabata - DNA Research , 2002
"... The entire genome of a thermophilic unicellular cyanobacterium, Thermosynechococcus elongatus BP-1, was sequenced. The genome consisted of a circular chromosome 2,593,857 bp long, and no plasmid was detected. A total of 2475 potential protein-encoding genes, one set of rRNA genes, 42 tRNA genes repr ..."
Abstract - Cited by 55 (3 self) - Add to MetaCart
The entire genome of a thermophilic unicellular cyanobacterium, Thermosynechococcus elongatus BP-1, was sequenced. The genome consisted of a circular chromosome 2,593,857 bp long, and no plasmid was detected. A total of 2475 potential protein-encoding genes, one set of rRNA genes, 42 tRNA genes

Circulating MicroRNAs as a Novel Class of Diagnostic Biomarkers in Gastrointestinal Tumors Detection: A Meta-Analysis Based on 42 Articles

by Ran Wang, Hong Wen, Yongcheng Xu, Qiulan Chen, Yi Luo, Yiqin Lin, Yu Luo, Angao Xu
"... Objective: MicroRNAs (miRNAs) have become the focus of most recent efforts in cancer research. However, there have been inconsistencies in the literature regarding the suitability of circulating miRNAs for early detection of gastrointestinal cancers. This study aims to assess the diagnostic performa ..."
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performance of circulating miRNAs in detection of gastrointestinal cancer through a meta-analysis. Methods: Eligible studies were selected by conducting a systematic literature search of public databases. The sensitivity and specificity were used to plot the summary receiver operator characteristic (SROC

TGF-b/Smad2/3 Signaling Directly Regulates Several miRNAs in Mouse ES Cells and Early Embryos

by Nicholas Redshaw, Carme Camps, Vikas Sharma, Mehdi Motallebipour, Marcela Guzman-ayala
"... The Transforming Growth Factor-b (TGF-b) signaling pathway is one of the major pathways essential for normal embryonic development and tissue homeostasis, with anti-tumor but also pro-metastatic properties in cancer. This pathway directly regulates several target genes that mediate its downstream fu ..."
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are the transcription factors of the pathway, and a specific inhibitor that blocks their activation. By performing short RNA deep-sequencing after 12 hours Smad2/3 activation and after 16 hours inhibition, we generated a database of responsive miRNAs. Promoter/enhancer analysis of a subset of these miRNAs revealed

Identification of typical miRNAs and target genes in hepatocellular carcinoma by DNA microarray technique

by T.-L He , K.-L Zheng , G Li , B Song , Y.-J Zhang , MD Yijie Zhang , ;
"... Abstract. -OBJECTIVES: The purpose of this study was to identify featured miRNAs of hepatocellular carcinoma (HCC) by comparing normal and cancer cell line samples and find potential utility as biomarkers for early diagnosis and treatment of HCC. MATERIALS AND METHODS: We downloaded the gene expres ..."
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bioinformatics methods. Target genes of these miRNAs were predicted using miRTarBase and miRecords databases. STRING software was used to construct the interaction network of target genes. Finally, we made module analysis by using Cytoscape software and its plugins -MCODE and BiNGO. RESULTS: A total of 40

Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One 3(5): e2141

by A Dixon-mciver, Phil East, Charles A. Mein, Jean-baptiste Cazier, Gael Molloy, Chaplin T. Andrew Lister , 2008
"... Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A quantitative expression profile analysis of 157 mature miRNAs was performed on 100 AML patients representing the spectrum of known karyotypes commo ..."
Abstract - Cited by 20 (0 self) - Add to MetaCart
set with respect to bone marrow from healthy donors. Fluorescent in situ hybridisation analysis using miRNA-specific locked nucleic acid (LNA) probes on cryopreserved patient cells confirmed the results obtained by real-time PCR. This study, conducted on about a fifth of the miRNAs currently reported

unknown title

by unknown authors
"... Abstract. MicroRNAs (miRNAs) are important in the regulation of cell growth, differentiation, apoptosis and carcinogenesis. The overexpression of oncogenic miRNAs or the underexpression of tumor suppressor miRNAs exhibits a critical function in the tumorigenesis of oral cancer. The aim of the presen ..."
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downloaded from the GEO database and an independent sample t-test was used to identify statistical differ-ences between the DE-miRNAs of the oral cancer patients and the healthy control subjects. The target genes of DE-miRNA were retrieved from the miRecords database. Furthermore, a protein

RESEARCH ARTICLE A Ranking-Based Meta-Analysis Reveals Let-7 Family as a Meta-Signature for Grade Classification in Breast Cancer

by Yasemin Oztemur, Tufan Bekmez, Alp Aydos, Isik G. Yulug, Betul Bozkurt
"... Breast cancer is one of the most important causes of cancer-related deaths worldwide in women. In addition to gene expression studies, the progressing work in the miRNA area including miRNA microarray studies, brings new aspects to the research on the cancer de-velopment and progression. Microarray ..."
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, and combined by a newly developed ranking-based meta-analysis approach to find out candidate miRNA bio-markers (meta-miRNAs) that classify breast cancers according to their grades and explain the relation between miRNAs and mRNAs. This approach provided meta-miRNAs specific to breast cancer grades, pointing

Kallikrein-related peptidase 5 induces miRNA-mediated anti- oncogenic pathways in breast cancer

by Konstantinos G. Sidiropoulos, Nicole M. A. White, Anna Bui, Qiang Ding, Peter Boulos, Georgios Pampalakis, Heba Khella, Joseph N. Samuel, George M. Yousef
"... This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Kallikrein-related peptidase 5 (KLK5) displays aberrant expressi ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
-regulated upon KLK5 expression. Extracellular matrix (ECM) molecules and cell-adhesion pathways were the most significant KLK5-induced miRNA-mediated regulatory targets. Validation from The Cancer Genome Atlas (TCGA) database indicated KLK5 was specifically down-regulated in luminal B and basal-like breast
Results 1 - 10 of 33