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doi:10.1093/nar/gkq929 COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
, 2010
"... COSMIC ..."
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
- Br J Cancer
, 2004
"... The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website ..."
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The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database
Original article Data mining using the Catalogue of Somatic Mutations in Cancer BioMart
"... providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just over 19 000 genes, 161 787 coding mutations and 5573 gene fusions, described in more than 577 000 tumour samples. COSMICMart (COSMIC BioMart) provides a flexible way to mine thes ..."
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providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just over 19 000 genes, 161 787 coding mutations and 5573 gene fusions, described in more than 577 000 tumour samples. COSMICMart (COSMIC BioMart) provides a flexible way to mine
Cancer Genome Consortium, and publicly available catalogs such as the Catalogue of Somatic Mutations in Cancer and
"... Advances in diagnostics and targeted therapies during the pastdecadehavechangedhowoncology is viewed. “Stratified medicine ” has emerged from the accumulated evidence gar-nered frommatching targeted therapies with tumor molecu-lar aberrations. Concomitantly, current knowledge derived from large-scal ..."
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Advances in diagnostics and targeted therapies during the pastdecadehavechangedhowoncology is viewed. “Stratified medicine ” has emerged from the accumulated evidence gar-nered frommatching targeted therapies with tumor molecu-lar aberrations. Concomitantly, current knowledge derived from large-scale, massively parallel sequencing technologies
Cancer Genome Consortium, and publicly available catalogs such as the Catalogue of Somatic Mutations in Cancer and
"... Advances in diagnostics and targeted therapies during the pastdecadehavechangedhowoncology is viewed. “Stratified medicine ” has emerged from the accumulated evidence gar-nered frommatching targeted therapies with tumor molecu-lar aberrations. Concomitantly, current knowledge derived from large-scal ..."
Abstract
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Advances in diagnostics and targeted therapies during the pastdecadehavechangedhowoncology is viewed. “Stratified medicine ” has emerged from the accumulated evidence gar-nered frommatching targeted therapies with tumor molecu-lar aberrations. Concomitantly, current knowledge derived from large-scale, massively parallel sequencing technologies
Editorial The continuing search for cancer-causing somatic mutations
, 2007
"... It is known that cancer is caused by an accumulation of mutations in DNA. Many genes have been associated with tumour progression either through germline or somatic mutations, but mutations in these genes by no means account for all instances of the disease. The availability of the completed human g ..."
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It is known that cancer is caused by an accumulation of mutations in DNA. Many genes have been associated with tumour progression either through germline or somatic mutations, but mutations in these genes by no means account for all instances of the disease. The availability of the completed human
PROCEEDINGS Open Access Somatic mutations in cancer development
, 2009
"... The transformation of a normal cell into a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic mutations: thus, cancer can be regarded properly as a genetic disease of somatic cells. The analogy between evolution of organisms and evolution of cell populat ..."
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The transformation of a normal cell into a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic mutations: thus, cancer can be regarded properly as a genetic disease of somatic cells. The analogy between evolution of organisms and evolution of cell
Integrative genomic analysis reveals somatic mutations in pheochromocytoma and
, 2011
"... Pheochromocytomas and paragangliomas are neuroendocrine tumors that occur in the context of inherited cancer syndromes in ∼30% of cases and are linked to germline mutations in the VHL, RET, NF1, SDHA, SDHB, SDHC, SDHD, SDHAF2 and TMEM127 genes. Although genome-wide expression studies have revealed ..."
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Cited by 5 (3 self)
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investigated 202 pheochromocytomas/paragangliomas, including 75 hereditary tumors, using expression profiling, BAC array comparative genomic hybridization and somatic mutation screening. Gene expression signatures defined the hereditary tumors according to their genotype and notably, led to a complete
H (2013) Identification of candidate genes for lung cancer somatic mutation test kits. Genetics and molecular biology 36(3): 455–464. doi: 10.1590/S141547572013000300022 PMID: 24130455
"... Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer. The ability to identify the actual sequence of gene mutations may help doctors determine which mutations lead to precancerous lesi ..."
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Cited by 1 (0 self)
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lesions and which produce invasive carcinomas, especially using next-generation sequencing (NGS) technology. In this study, we analyzed the latest lung cancer data in the COSMIC database, in order to find genomic “hotspots ” that are frequently mutated in human lung cancer genomes. The results revealed
CancerGenes: a gene selection resource for cancer genome projects
- Nucl. Acids Res
, 2007
"... The genome sequence framework provided by the human genome project allows us to precisely map human genetic variations in order to study their association with disease and their direct effects on gene function. Since the description of tumor suppressor genes and oncogenes several decades ago, both g ..."
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Cited by 47 (0 self)
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germ-line variations and somatic mutations have been established to be important in cancer—in terms of risk, oncogenesis, prognosis and response to therapy. The Cancer Genome Atlas initiative proposed by the NIH is poised to elucidate the contribution of somatic mutations to cancer development
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