mammalian protein complexes

protein complexes—2009

between genes in different organisms with a high degree of reliability. For example, orthologs of human proteins are often functionally characterized in model organisms. Unfortunately, orthology analysis between human and e.g. invertebrates is often complex because of large numbers of paralogs within

Piwi-interacting RNAs (piRNAs) are expressed in mammalian germline cells and have been identified as key players in germline development. These molecules, typically of length 25–33 nt, associate with Piwi proteins of the Argonaute family to form the Piwi-interacting RNA complex. These small

and to foster a new coherence in the coordinated development of screening technologies and the sharing of underpinning resources. This would not only invigorate gene function analysis but also enable new cross-taxon analysis of genome evolution. The workshop was organized by Andrew Cossins (Liverpool, UK

Neuropeptides regulate cell-cell signaling and influence many biological processes in vertebrates, including development, growth, and reproduction. The complex processing of neuropeptides from prohormone proteins by prohormone convertases, combined with the evolutionary distance between the chicken

education on the internet, free of charge, a real possibility. At this pivotal moment it is appropriate to explore the potential for obtaining comprehensive bioinformatics training with currently existing free video resources. This article pre-sents such a bioinformatics curric-ulum in the form of a virtual

with extracellular matrix genes during lung development. These data should serve as a resource for the pulmonary research community and assist in deciphering the molecular mechanisms governing normal lung development as well as those involved in aberrant developmental pathology. Mammalian lung development is a

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This report focuses on the evidence about the health.consequences of smoking for women, and is intended to serve.the public health and medical communities as 'a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including trends in consumption, biomedical evidence, and determinants of smoking ititiation, maintenance, and cessation. The biomedical aspects ofsmoking are presented in terms of mortality, morbiplity, cardiovasculaidiseases, cancer, pregnancy and infant,health,, Teptic ulcer disease, drug reactions and, interactions, food constituents, and responses to,diagnostic tests. The psychosocial and behavioraj. aspects, of smoking in women are discussed, along with the docffiented increases in- the risk of contracting lung cancer, heart,disease, or lung disease. The harmful effects of pregnant mothers smoking behaviors, are also docudented. Adhitionally, recent data are enumerated to indicate a trend of,decreasing tobacco usage among women in response to the warnings of the gavernMent, voluntary agencie, and physicrins. (Author /NRB)' DOCUMENT RESUME cc 015 465