in the region with larger demand, but the location of demand itself depends on the distribution of manufacturing. Emergence of a core-periphery pattern depends on transportation costs, economies of scale, and the share of manufacturing in national income. The study of economic geography-of the location

Grant CA 36409, and Research Scientist Development Award MH 00311 from the National Institute of Mental Health to Shelley E. Taylor. Jonathon D. Brown was supported by a University of California, Los Angeles, Chancellor's fellowship and by a Southern Methodist University new-faculty seed grant. We

failures, and the mean time to repair. We find for example that average failure rates differ wildly across systems, ranging from 20–1000 failures per year, and that time between failures is modeled well by a Weibull distribution with decreasing hazard rate. From one system to another, mean repair time

. The uncertainty in the published estimates for BC emissions is a factor of two to five on regional scales and at least 50% on global scales. High BC emissions ( Regional hotspots Until about the 1950s, North America and Western Europe were the major sources of soot emissions, but now developing nations

-bilities. In this paper, we present Grid’5000, a 5000 CPU nation-wide infrastructure for research in Grid computing. Grid’5000 is designed to provide a scientific tool for com-puter scientists similar to the large-scale instruments used by physicists, astronomers, and biologists. We describe the motivations, design

;reflection" paths) to generate improved iterates. The reflective Newton approach does not require identification of an "activity set". In this report we establish that the reflective Newton approach is globally and quadratically convergent. Moreover, we develop a specific example of this general

education on the internet, free of charge, a real possibility. At this pivotal moment it is appropriate to explore the potential for obtaining comprehensive bioinformatics training with currently existing free video resources. This article pre-sents such a bioinformatics curric-ulum in the form of a virtual

for developing bioinformatics database systems. Generally, we argue that large-scale engineering principles can be successfully adapted from disciplines such as software engineering and data management, and that having an in-the-large perspective will be a key advantage in the next phase of bioinformatics

publicly paper and electronic copies of this gocument in whole iart.

sociological theory able to grasp emerging forms of social organization and con ict. This theory is still in its explorator y stage, and should remain, like all relevant theories, as a work in progress open to recti cation by empirical research. Because I am trying to distill theory from observation, I