Results 1 - 10 of 29

A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory. Ann Neurol 47: 36–45

by C. J. Mummery, R. S. J. Frackowiak Frcp, J. R. Hodges, Semantic Memory Ann Neurol , 2000
"... The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age-matched normal subjects by using voxel-based morphometry, a technique that identifies changes in gray matter volume on a voxel-by-voxel basis. A ..."
Abstract - Cited by 77 (11 self) - Add to MetaCart
correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent

PAPER Medial temporal lobe atrophy predicts Alzheimer’s disease in patients with minor cognitive impairment

by P J Visser, F R J Verhey, P A M Hofman, P Scheltens, J Jolles
"... Objectives: To investigate whether medial temporal lobe atrophy predicted outcome in patients with minor cognitive impairment and whether assessment of the medial temporal lobe could increase the predictive accuracy of age and delayed recall for outcome. Quantitative and qualitative methods of asses ..."
Abstract - Add to MetaCart
, volumetry of the parahippocampal gyrus, and qualitative rating of medial temporal lobe atrophy (MTA). Outcome measures were Alzheimer type dementia or cognitive decline at follow up. Delayed recall was tested with a verbal learning test. Results: Ten patients had experienced cognitive decline at follow up

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

by A. David Smith, Stephen M. Smith, Celeste A. De Jager, Carole Johnston, Grzegorz Agacinski, Abderrahim Oulhaj, Kevin M. Bradley, Robin Jacoby, Helga Refsum
"... Background: An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administratio ..."
Abstract - Cited by 5 (0 self) - Add to MetaCart
groups of equal size, one treated with folic acid (0.8 mg/d), vitamin B12 (0.5 mg/d) and vitamin B6 (20 mg/d), the other with placebo; treatment was for 24 months. The main outcome measure was the change in the rate of atrophy of the whole brain assessed by serial volumetric MRI scans. Results: A total

The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst

by C. E. Denby, S. D. Vann, D. Tsivilis, J. P. Aggleton, D. Montaldi, N. Roberts, A. R. Mayes - AJNR Am J Neuroradiol , 2009
"... BACKGROUND AND PURPOSE: Patients who have had a colloid cyst removed from the third ventricle sometimes experience some difficulty with day-to-day memory. This study provided quantitative MR imaging volume measures of 1 structure potentially responsible for mnemonic problems, the mam-millary bodies. ..."
Abstract - Cited by 1 (1 self) - Add to MetaCart
of stereologic volume-estimation techniques. For the mammillary body measures, 2 groups of MR images were assessed (0.8- and 1.0-mm section thickness) to compare the sensitivity of each imaging sequence for detecting any atrophy. Other structures associated with memory processes, such as the hippocampus

RESEARCH ARTICLE Cortical Thickness, Surface Area and Volume Measures in Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy

by A Worker, Camilla Blain, Jozef Jarosz, K. Ray Chaudhuri, Gareth J. Barker, Steven C. R. Williams, Richard Brown, P. Nigel Leigh, Andrew Simmons
"... Objective: Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was to use surface-based analysis techniques to assess cortical thickness, su ..."
Abstract - Add to MetaCart
Objective: Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are neurodegenerative diseases that can be difficult to distinguish clinically. The objective of the current study was to use surface-based analysis techniques to assess cortical thickness

In vivo quantification of brain volumes in subcortical vascular dementia and Alzheimer’s disease. An MRI-based study. Dementia and geriatric cognitive disorders 9

by J Pantel , J Schröder , M Essig , M Jauss , G Schneider , K Eysenbach , R Von Kummer , K Baudendistel , L R Schad , M V Knopp , 1998
"... Abstract Quantitative magnetic resonance imaging (MRI) was used to assess global and regional cerebral volumes in patients with a clinical diagnosis of subcortical vascular dementia (VD) and Alzheimer's disease (AD). Whole brain volume, cerebrospinal fluid volume, volumes of the temporal, fron ..."
Abstract - Cited by 4 (1 self) - Add to MetaCart
differences between controls and dementia groups with respect to all morphological parameters. However, apart from the volume of the cerebellum no significant volumetric differences were found between VD and AD. These results indicate that MRI-based volumetry allows differentiation between AD or VD from

Temporal lobe rating scale: application to Alzheimer’s disease and frontotemporal

by C J Galton, B Gomez-anson, N Antoun, P Scheltens, K Patterson, M Graves, B J Sahakian, J R Hodges , 2001
"... Objectives—Temporal lobe atrophy as as-sessed by MRI can be measured in several ways. Volumetric measurements are quantitative but very time consuming and require extensive training to perform, so are not easily transferable to clinical prac-tice. Visual rating scales, by contrast, are quick and wid ..."
Abstract - Cited by 11 (1 self) - Add to MetaCart
Objectives—Temporal lobe atrophy as as-sessed by MRI can be measured in several ways. Volumetric measurements are quantitative but very time consuming and require extensive training to perform, so are not easily transferable to clinical prac-tice. Visual rating scales, by contrast, are quick

Understanding social dysfunction in the behavioural variant of front temporal dementia: the role of emotion and sarcasm processing. Brain A

by C M Kipps , P J Nestor , J Acosta-Cabronero , R Arnold , J R Hodges , Prof. J R Hodges - Journal of Neurology , 2009
"... Abstract Social interaction is profoundly affected in the behavioural form of frontotemporal dementia (bvFTD) yet there are few means of objectively assessing this. Diagnosis of bvFTD is based on informant report, however a number of individuals with a clinical profile consistent with the disease h ..."
Abstract - Cited by 9 (2 self) - Add to MetaCart
in bvFTD which indexes the frontotemporal volume loss in bvFTD patients and provides an objective measure for separating behavioural patients who are likely to decline from those who may remain stable. These results provide additional evidence for the role of the orbitofrontal cortex and related

Near-Infrared Brain Volumetric Imaging Method: A Monte Carlo Study

by Ching-cheng Chuang, Pei-ning Wang, Wei-ta Chen, Tsuo-hung Lan, Chung-ming Chen, Yao-sheng Hsieh, Chun-yang Wang, Chia-wei Sun
"... Abstract—The symptom of brain volumetric changes may pro-vide significant biomarker to predict progressive dementia. The brain volumetric changes of prefrontal cortex are highly associated with many neurodegenerative diseases. Besides, brain atrophy re-veals the expanded interhemispheric fissure and ..."
Abstract - Add to MetaCart
Abstract—The symptom of brain volumetric changes may pro-vide significant biomarker to predict progressive dementia. The brain volumetric changes of prefrontal cortex are highly associated with many neurodegenerative diseases. Besides, brain atrophy re-veals the expanded interhemispheric fissure

Magnetization Transfer Ratio in Alzheimer Disease: Comparison with Volumetric Measurements

by B. H. Ridha, M. R. Symms, D. J. Tozer, C. Frost, M. M. Siddique, E. B. Lewis, D. G. Macmanus, P. A. Boulby, G. J. Barker, M. N. Rossor, N. C. Fox, P. S. Tofts
"... BACKGROUND AND PURPOSE: Alzheimer disease (AD) is accompanied by macroscopic atrophy on volu-metric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value of measuri ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
BACKGROUND AND PURPOSE: Alzheimer disease (AD) is accompanied by macroscopic atrophy on volu-metric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value
Results 1 - 10 of 29