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4,674
A Field Study of the Software Design Process for Large Systems
- Communications of the ACM
, 1988
"... The problems of designing large software systems were studied through interviewing personnel from 17 large projects. A layered behavioral model is used to analyze how three lgf these problems-the thin spread of application domain knowledge, fluctuating and conflicting requirements, and communication ..."
Abstract
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Cited by 685 (2 self)
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The problems of designing large software systems were studied through interviewing personnel from 17 large projects. A layered behavioral model is used to analyze how three lgf these problems-the thin spread of application domain knowledge, fluctuating and conflicting requirements
Motivation through the Design of Work: Test of a Theory. Organizational Behavior and Human Performance,
, 1976
"... A model is proposed that specifies the conditions under which individuals will become internally motivated to perform effectively on their jobs. The model focuses on the interaction among three classes of variables: (a) the psychological states of employees that must be present for internally motiv ..."
Abstract
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Cited by 622 (2 self)
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in seven organizations, and results support its validity. A number of special features of the model are discussed (including its use as a basis for the diagnosis of jobs and the evaluation of job redesign projects), and the model is compared to other theories of job design. Work redesign is becoming
Three-dimensional object recognition from single two-dimensional images
- Artificial Intelligence
, 1987
"... A computer vision system has been implemented that can recognize threedimensional objects from unknown viewpoints in single gray-scale images. Unlike most other approaches, the recognition is accomplished without any attempt to reconstruct depth information bottom-up from the visual input. Instead, ..."
Abstract
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Cited by 484 (7 self)
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, a probabilistic ranking method is used to reduce the size of the search space during model based matching. Finally, a process of spatial correspondence brings the projections of three-dimensional models into direct correspondence with the image by solving for unknown viewpoint and model parameters
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/ genome databases
- Nucleic Acids Res
, 2012
"... The MetaCyc database (MetaCyc.org) is a compre-hensive and freely accessible database describing metabolic pathways and enzymes from all domains of life. MetaCyc pathways are experimentally determined, mostly small-molecule metabolic pathways and are curated from the primary scien-tific literature. ..."
Abstract
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Cited by 404 (15 self)
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. MetaCyc contains>2100 pathways derived from>37000 publications, and is the largest curated collection of metabolic pathways currently available. BioCyc (BioCyc.org) is a collec-tion of>3000 organism-specific Pathway/Genome Databases (PGDBs), each containing the full genome and predicted
Protein structure prediction and structural genomics
- Science
, 2001
"... Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information abou ..."
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Cited by 332 (14 self)
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Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information
From frequency to meaning : Vector space models of semantics
- Journal of Artificial Intelligence Research
, 2010
"... Computers understand very little of the meaning of human language. This profoundly limits our ability to give instructions to computers, the ability of computers to explain their actions to us, and the ability of computers to analyse and process text. Vector space models (VSMs) of semantics are begi ..."
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Cited by 347 (3 self)
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, yielding three classes of applications. We survey a broad range of applications in these three categories and we take a detailed look at a specific open source project in each category. Our goal in this survey is to show the breadth of applications of VSMs for semantics, to provide a new perspective
Entrez Gene: gene-centered information at NCBI
- Nucleic Acids Res
, 2007
"... Entrez Gene (www.ncbi.nlm.nih.gov/entrez/query. fcgi?db=gene) is NCBI’s database for gene-specific information. Entrez Gene includes records from genomes that have been completely sequenced, that have an active research community to con-tribute gene-specific information or that are sched-uled for in ..."
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Cited by 340 (12 self)
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-uled for intense sequence analysis. The content of Entrez Gene represents the result of both curation and automated integration of data from NCBI’s Reference Sequence project (RefSeq), from collabo-rating model organism databases and from other databases within NCBI. Records in Entrez Gene are assigned unique
Pad -- An Alternative Approach to the Computer Interface
- IN PROC. ACM SIGGRAPH
, 1993
"... We believe that navigation in information spaces is best supported by tapping into our natural spatial and geographic ways of thinking. To this end, we are developing a new computer interface model called Pad. The ongoing Pad project uses a spatial metaphor for computer interface design. It provides ..."
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Cited by 333 (2 self)
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We believe that navigation in information spaces is best supported by tapping into our natural spatial and geographic ways of thinking. To this end, we are developing a new computer interface model called Pad. The ongoing Pad project uses a spatial metaphor for computer interface design
Policy driven management of distributed systems
- Journal of Network and Systems Management
, 1994
"... Separating management policy from the automated managers which interpret the policy facilitates the dynamic change of behaviour of a distributed management system. This permits it to adapt to evolutionary changes in the system being managed and to new application requirements. Changing the behaviour ..."
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Cited by 301 (29 self)
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between subjects (managers) and targets (managed objects). Domains are used to group the objects to which a policy applies. Policy objects also have attributes specifying the action to be performed and constraints limiting the applicability of the policy. We show how a number of example policies can
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485: 376–380
, 2012
"... The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct chromosome territories (CT), and numerous m ..."
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Cited by 219 (4 self)
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resolution. We identify large, megabase-sized local chromatin interaction domains, which we term “topological domains”, as a pervasive structural feature of the genome organization. These domains correlate with regions of the genome that constrain the spread of heterochromatin. The domains are stable across
Results 1 - 10
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4,674
