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Development of a Clinical Pathways Analysis System with Adaptive Bayesian Nets and Data Mining Techniques

by unknown authors
"... Abstract: The use and development of software in the medical field offers tremendous opportunities for making health care delivery more efficient, more effective, and less error-prone. We discuss and explore the use of clinical pathways analysis with Adaptive Bayesian Networks and Data Mining Techn ..."
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Abstract: The use and development of software in the medical field offers tremendous opportunities for making health care delivery more efficient, more effective, and less error-prone. We discuss and explore the use of clinical pathways analysis with Adaptive Bayesian Networks and Data Mining

An Optimal Approach for Mining Rare Causal Associations to Detect ADR Signal Pairs

by unknown authors
"... Abstract- Adverse Drug Reaction (ADR) is one of the most important issues in the assessment of drug safety. In fact, many adverse drug reactions are not discovered during limited premarketing clinical trials; instead, they are only observed after long term post-marketing surveillance of drug usage. ..."
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and innovative data mining techniques, the proposed system not only supports OLAP style multidimensional analysis of ADRs, but also allows the interactive discovery of associations between drugs and symptoms, called a drug-ADR association rule, which can be further, developed using other factors of interest

Pathway-Finder: An Interactive Recommender System for Supporting Personalized Care Pathways

by Rui Liu, Raj Velamur Srinivasan, Kiyana Zolfaghar, Si-chi Chin, Senjuti Basu Roy, Ankur Teredesai
"... Abstract—Clinical pathways define the essential component of the complex care process, with the objective to optimize patient outcomes and resource allocation. Clinical pathway analysis has gained increasing attention in order to automate the patient treatment process. In this demonstration paper, w ..."
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Abstract—Clinical pathways define the essential component of the complex care process, with the objective to optimize patient outcomes and resource allocation. Clinical pathway analysis has gained increasing attention in order to automate the patient treatment process. In this demonstration paper

Altered plasma proteome during an early phase of peritonitis-induced sepsis

by Visith Thongboonkerd , Wararat Chiangjong , Jan Mares , Jiri Moravec , Zdenek Tuma , Thomas Karvunidis , Supachok Sinchaikul , Shui-Tein Chen , Karel Opatrný Jr , Martin Matejovic , 2009
"... A B S T R A C T Sepsis is a systemic response to infection commonly found in critically ill patients and is associated with multi-organ failure and high mortality rate. Its pathophysiology and molecular mechanisms are complicated and remain poorly understood. In the present study, we performed a pr ..."
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proteomics investigation to characterize early host responses to sepsis as determined by an altered plasma proteome in a porcine model of peritonitis-induced sepsis, which simulated several clinical characteristics of human sepsis syndrome. Haemodynamics, oxygen exchange, inflammatory responses, oxidative

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP Inhibitors. PLoS Comput Biol 2009; 5: e1000387

by Li Xie, Thomas Evangelidis, Lei Xie, Philip E. Bourne
"... Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anti-cancer effects to the suppression of the Akt signaling pathway, but the actual molecular targets remain unknown. Using a structural proteome-wide off-target pipeline, which i ..."
Abstract - Cited by 45 (4 self) - Add to MetaCart
Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anti-cancer effects to the suppression of the Akt signaling pathway, but the actual molecular targets remain unknown. Using a structural proteome-wide off-target pipeline, which

Robustness and Plasticity of Metabolic Pathway Flux among Uropathogenic Isolates of Pseudomonas aeruginosa

by Antje Berger, Katrin Dohnt, Petra Tielen, Dieter Jahn, Judith Becker, Christoph Wittmann , 2013
"... Pseudomonas aeruginosa is a human pathogen that frequently causes urinary tract and catheter-associated urinary tract infections. Here, using 13C-metabolic flux analysis, we conducted quantitative analysis of metabolic fluxes in the model strain P. aeruginosa PAO1 and 17 clinical isolates. All P. ae ..."
Abstract - Cited by 3 (0 self) - Add to MetaCart
Pseudomonas aeruginosa is a human pathogen that frequently causes urinary tract and catheter-associated urinary tract infections. Here, using 13C-metabolic flux analysis, we conducted quantitative analysis of metabolic fluxes in the model strain P. aeruginosa PAO1 and 17 clinical isolates. All P

Review Article Addressing the Common Pathway Underlying Hypertension and Diabetes in People Who Are Obese by Maximizing Health: The Ultimate Knowledge Translation Gap

by Elizabeth Dean, Constantina Lomi, Selma Bruno, Hamzeh Awad
"... which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In accordance with the WHO definition of health, this article examines the alarming discord between the epidemiology of hypertension, type 2 diabetes mellitus (T2DM), and obesi ..."
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which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In accordance with the WHO definition of health, this article examines the alarming discord between the epidemiology of hypertension, type 2 diabetes mellitus (T2DM

USING SIMULATION IN HOSPITAL LAYOUT PLANNING

by C. Laroque, J. Himmelspach, R. Pasupathy, O. Rose, A. M. Uhrmacher, Ines Arnolds, Stefan Nickel, Sara Shashaani, Christian Wernz
"... The quality and performance of a hospital layout during daily operations highly depends on patient and personnel flows. The travelling routes are influenced by the stochasticity of clinical pathways due to the patients ’ recovery processes. To account for this stochasticity when planning a hospital ..."
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The quality and performance of a hospital layout during daily operations highly depends on patient and personnel flows. The travelling routes are influenced by the stochasticity of clinical pathways due to the patients ’ recovery processes. To account for this stochasticity when planning a hospital

Interactive visualization of volumetric white matter connectivity in DT-MRI using a parallel-hardware Hamilton-Jacobi solver

by Won-ki Jeong, Student Member, P. Thomas Fletcher, Ran Tao, Ross T. Whitaker Member - in Proceedings of the IEEE Visualization , 2007
"... Abstract—In this paper we present a method to compute and visualize volumetric white matter connectivity in diffusion tensor magnetic resonance imaging (DT-MRI) using a Hamilton-Jacobi (H-J) solver on the GPU (Graphics Processing Unit). Paths through the volume are assigned costs that are lower if t ..."
Abstract - Cited by 19 (7 self) - Add to MetaCart
if they are consistent with the preferred diffusion directions. The proposed method finds a set of voxels in the DTI volume that contain paths between two regions whose costs are within a threshold of the optimal path. The result is a volumetric optimal path analysis, which is driven by clinical and scientific questions

Perspective An Online Bioinformatics Curriculum

by David B. Searls
"... Abstract: Online learning initia-tives over the past decade have become increasingly comprehen-sive in their selection of courses and sophisticated in their presen-tation, culminating in the recent announcement of a number of consortium and startup activities that promise to make a university educat ..."
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Abstract: Online learning initia-tives over the past decade have become increasingly comprehen-sive in their selection of courses and sophisticated in their presen-tation, culminating in the recent announcement of a number of consortium and startup activities that promise to make a university
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