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Results 1 - 10
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225
Human DNA methylomes at base resolution show widespread epigenomic differences.
- Nature,
, 2009
"... DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryo ..."
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Cited by 401 (6 self)
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DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human
A Human MAP Kinase Interactome
"... Mitogen Activated Protein Kinase (MAPK) pathways form the backbone of signal transduction within the mammalian cell. Here, we apply a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these da ..."
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Mitogen Activated Protein Kinase (MAPK) pathways form the backbone of signal transduction within the mammalian cell. Here, we apply a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble
An in Vivo Map of the Yeast Protein Interactome
"... Protein interactions regulate the systems-level behavior of cells; thus, deciphering the structure and dynamics of protein interaction networks in their cellular context is a central goal in biology. We have performed a genome-wide in vivo screen for protein-protein interactions in Saccharomyces cer ..."
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Cited by 1 (0 self)
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interactome. The PCA detected structural and topological relationships between proteins, providing an 8-nanometer–resolution map of dynamically interacting complexes in vivo and extended networks that provide insights into fundamental cellular processes, including cell polarization and autophagy, pathways
A Draft of the Human Septin Interactome
"... Background: Septins belong to the GTPase superclass of proteins and have been functionally implicated in cytokinesis and the maintenance of cellular morphology. They are found in all eukaryotes, except in plants. In mammals, 14 septins have been described that can be divided into four groups. It has ..."
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Cited by 1 (0 self)
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. It has been shown that mammalian septins can engage in homo- and heterooligomeric assemblies, in the form of filaments, which have as a basic unit a hetero-trimeric core. In addition, it has been speculated that the septin filaments may serve as scaffolds for the recruitment of additional proteins
The yeast interactome (unit: g303204)
"... 19 manuscript pages 9 illustrations 1 table ~6200 words (including references) ~4600 words (excluding references) Key Words: proteomics, network, two-hybrid system, mass spectrometry, interaction map, interactome, yeast, protein complex, synthetic lethality, genetic interaction This is a preprint fr ..."
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19 manuscript pages 9 illustrations 1 table ~6200 words (including references) ~4600 words (excluding references) Key Words: proteomics, network, two-hybrid system, mass spectrometry, interaction map, interactome, yeast, protein complex, synthetic lethality, genetic interaction This is a preprint
Mining Alzheimer Disease Relevant Proteins from Integrated Protein Interactome Data
- Pac. Symp. Biocomput
, 2006
"... Huge unrealized post-genome opportunities remain in the understanding of detailed molecular mechanisms for Alzheimer Disease (AD). In this work, we developed a computational method to rank-order AD-related proteins, based on an initial list of AD-related genes and public human protein interaction da ..."
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Cited by 21 (7 self)
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Huge unrealized post-genome opportunities remain in the understanding of detailed molecular mechanisms for Alzheimer Disease (AD). In this work, we developed a computational method to rank-order AD-related proteins, based on an initial list of AD-related genes and public human protein interaction
LETTER Landscape of protein domain interactome Dear Editor,
"... Protein domain is usually defined as distinct, compact and stable protein structural unit that folds independently of other such units (Koonin et al., 2002). The majority of proteins, especially in higher organisms, contain multiple domains (Chothia, 1992). Domain view of protein evolution provides ..."
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established a baseline human protein-protein inter-action network composed of 19,139 individual PPIs by in-tegrating several protein-protein interaction databases. We then mapped domains into the PPI network based on Pfam definitions (Sonnhammer et al., 1998). We used information
A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human
"... SUMMARY Here, we present FissionNet, a proteome-wide binary protein interactome for S. pombe, comprising 2,278 high-quality interactions, of which $50% were previously not reported in any species. FissionNet unravels previously unreported interactions implicated in processes such as gene silencing ..."
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SUMMARY Here, we present FissionNet, a proteome-wide binary protein interactome for S. pombe, comprising 2,278 high-quality interactions, of which $50% were previously not reported in any species. FissionNet unravels previously unreported interactions implicated in processes such as gene silencing
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol 2: e100
, 2006
"... Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and the amount of predicted structural disorder, the disorder propensities of proteins with various number ..."
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Cited by 52 (5 self)
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in hubs than in ends. A binary classification of hubs and ends into ordered and disordered subclasses using the consensus prediction method showed a significant enrichment of wholly disordered proteins and a significant depletion of wholly ordered proteins in hubs relative to ends in worm, fly, and human
The social network of a cell: Recent advances in interactome mapping,” Biotechnology annual review
, 2008
"... Abstract. Proteins very rarely act in isolation. Biomolecular interactions are central to all biological functions. In human, for example, interference with biomolecular networks often lead to disease. Protein-protein and protein-metabolite interactions have traditionally been studied one by one. R ..."
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Cited by 18 (0 self)
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Abstract. Proteins very rarely act in isolation. Biomolecular interactions are central to all biological functions. In human, for example, interference with biomolecular networks often lead to disease. Protein-protein and protein-metabolite interactions have traditionally been studied one by one
Results 1 - 10
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225
