We introduce a method of functionally classifying genes by using gene expression data from DNA microarray hybridization experiments. The method is based on the theory of support vector machines (SVMs). SVMs are considered a supervised computer learning method because they exploit prior knowledge

Software architectures shift the focus of developers from lines-of-code to coarser-grained architectural elements and their overall interconnection structure. Architecture description languages (ADLs) have been proposed as modeling notations to support architecture-based development. There is

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This thesis defines a set of program restructuring operations (refactorings) that support the design, evolution and reuse of object-oriented application frameworks. The focus of the thesis is on automating the refactorings in a way that preserves the behavior of a program. The refactorings

, there have been few serious attempts to cast agent systems as a software engineering paradigm. This paper seeks to rectify this omission. Specifically, it will be argued that: (i) the conceptual apparatus of agent-oriented systems is well-suited to building software solutions for complex systems and (ii

The purpose of this paper is to build the foundation for software architecture. We first develop an intuition for software architecture by appealing to several well-established architectural disciplines. On the basis of this intuition, we present a model of software architec-ture that consists

Ptolemy is an environment for simulation and prototyping of heterogeneous systems. It uses modern object-oriented software technology (C++) to model each subsystem in a natural and efficient manner, and to integrate these subsystems into a whole. Ptolemy encompasses practically all aspects

Dynamic binary instrumentation (DBI) frameworks make it easy to build dynamic binary analysis (DBA) tools such as checkers and profilers. Much of the focus on DBI frameworks has been on performance; little attention has been paid to their capabilities. As a result, we believe the potential of DBI

The problems of designing large software systems were studied through interviewing personnel from 17 large projects. A layered behavioral model is used to analyze how three lgf these problems-the thin spread of application domain knowledge, fluctuating and conflicting requirements

Drawing graphs is an important problem that combines flavors of computational geometry and graph theory. Applications can be found in a variety of areas including circuit layout, network management, software engineering, and graphics. The main contributions of this paper can be summarized