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Neurocomputational models of motor and cognitive deficits in Parkinson's disease

by Thomas V. Wiecki, Michael J. Frank - Progress in Brain Research , 2010
"... Abstract: We review the contributions of biologically constrained computational models to our understanding of motor and cognitive deficits in Parkinson’s disease (PD). The loss of dopaminergic neurons innervating the striatum in PD, and the well-established role of dopamine (DA) in reinforcement le ..."
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Abstract: We review the contributions of biologically constrained computational models to our understanding of motor and cognitive deficits in Parkinson’s disease (PD). The loss of dopaminergic neurons innervating the striatum in PD, and the well-established role of dopamine (DA) in reinforcement

Parkinson’s disease

by unknown authors
"... Recent models based, in part on a study of Huntington’s disease, suggest that the basal ganglia are involved in on-line movement guidance. Two experiments were conducted to investigate this idea. First, we studied advanced Parkinson’s disease patients performing a reaching task known to depend on on ..."
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Recent models based, in part on a study of Huntington’s disease, suggest that the basal ganglia are involved in on-line movement guidance. Two experiments were conducted to investigate this idea. First, we studied advanced Parkinson’s disease patients performing a reaching task known to depend

Visual Attention in PD Quantitative Modeling of Visual Attention Processes in Patients with Parkinson’s Disease: Effects of Stimulus Integrality on Selective Attention and Dimensional Integration

by J. Vincent Filoteo, W. Todd Maddox
"... Parkinson’s disease (PD) patients and normal controls were administered a series of visual attention tasks. The Dimensional Integration task required integration of information from two stimulus dimensions. The Selective Attention task required selective attention to one stimulus dimension while ign ..."
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Parkinson’s disease (PD) patients and normal controls were administered a series of visual attention tasks. The Dimensional Integration task required integration of information from two stimulus dimensions. The Selective Attention task required selective attention to one stimulus dimension while

Model of cortical-basal ganglionic processing: encoding the serial order of sensory events

by David G. Beiser, James, C. Houk, David G - J. Neurophysiol , 1998
"... ganglionic processing: encoding the serial order of sensory events. behavior. Subjects with frontal lobe lesions show impaired J. Neurophysiol. 79: 3168–3188, 1998. Several lines of evidence performance on tasks requiring organization of sequential suggest that the prefrontal (PF) cortex and basal g ..."
Abstract - Cited by 67 (0 self) - Add to MetaCart
ganglia are im- pointing responses (Petrides and Milner 1982; Wiegersma portant in cognitive aspects of serial order in behavior. We present et al. 1990), serial-order recognition (Kesner et al. 1994), a modular neural network model of these areas that encodes the serial order of events into spatial

Journal of Visualized Experiments www.jove.com Video Article Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of

by Yousuf O. Ali, Wilfredo Escala, Kai Ruan, R. Grace Zhai
"... Advances in genetic methods have enabled the study of genes involved in human neurodegenerative diseases using Drosophila as a model system 1. Most of these diseases, including Alzheimer's, Parkinson's and Huntington's disease are characterized by age-dependent deterioration in learni ..."
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Advances in genetic methods have enabled the study of genes involved in human neurodegenerative diseases using Drosophila as a model system 1. Most of these diseases, including Alzheimer's, Parkinson's and Huntington's disease are characterized by age-dependent deterioration

Spatial, but Not Object, Delayed Response Is Impaired in Early Parkinson's Disease

by Bradley R. Postle, Suzanne Corkin, John Jonides, Edward E. Smith, John H. Growdon, Bradley R. Postle, Suzanne Corkin, Department Of Brain
"... The authors hypothesized that the pathophysiology of early Parkinson's disease (PD) may selectively target structures that support visual working memory for spatial relations but leave structures that support working memory for featural characteristics of objects relatively intact Fifteen PD an ..."
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The authors hypothesized that the pathophysiology of early Parkinson's disease (PD) may selectively target structures that support visual working memory for spatial relations but leave structures that support working memory for featural characteristics of objects relatively intact Fifteen PD

Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model

by Of Parkinsonism, Nathalie Breysse, Christelle Baunez, Will Spooren, Fabrizio Gasparini, Marianne Amalric
"... Metabotropic glutamate receptors (mGluRs) have recently been considered as potential pharmacological targets in the treatment of neurodegenerative disorders and particularly in parkinsonism. Within the basal ganglia, receptors of group I (mGluR1 and mGluR5) are widely expressed; the present study wa ..."
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was thus aimed at blocking these receptors in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease in the rat. Considering the prominent expression of mGluR5, we have used the selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) to target these receptors. In rats trained to quickly

ORAL PRESENTATION Open Access Multiscale modeling of cortical information flow in Parkinson’s disease

by Cliff C Kerr, Sacha J Van Albada, Samuel A Neymotin, George L Chadderdon Iii, Peter A Robinson, William W Lytton
"... The basal ganglia play a crucial role in the execution of movements, as demonstrated by the severe motor defi-cits that accompany the neuronal degeneration under-lying Parkinson’s disease (PD). Since motor commands originate from the cortex, an important functional question is how the basal ganglia ..."
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The basal ganglia play a crucial role in the execution of movements, as demonstrated by the severe motor defi-cits that accompany the neuronal degeneration under-lying Parkinson’s disease (PD). Since motor commands originate from the cortex, an important functional question is how the basal ganglia

Restorative Effects of Platelet Derived Growth Factor-BB in Rodent Models of Parkinson’s Disease

by Olof Zachrissona, Ming Zhaob, Annica Anderssona, Karin Dannaeusa, Ruben Isacsona, Elisabet Nielsena, Cesare Patronea, Lilian Wikstroma, Kristofer Delfanib, Alison L. Mccormackc, Theo Palmerc, Donato A. Di Montec, Michael P. Hilld, Ann Marie, Janson Langb, Anders Haegerstr
"... Abstract. Parkinson’s disease is characterized by motor deficits caused by loss of midbrain dopaminergic neurons. Neurotrophic factors and cell transplantation have partially restored function in models of Parkinson’s disease, but have had limited effects in humans. Here we show that intracerebroven ..."
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Abstract. Parkinson’s disease is characterized by motor deficits caused by loss of midbrain dopaminergic neurons. Neurotrophic factors and cell transplantation have partially restored function in models of Parkinson’s disease, but have had limited effects in humans. Here we show

REVIEW Time perception impairs sensory-motor integration in Parkinson’s disease Open Access

by Marina Lucas, A Chaves, Silmar Teixeira, Diana Carvalho, Caroline Peressutti, Juliana Bittencourt, Bruna Velasques, Manuel Menéndez-gonzález, Mauricio Cagy, Roberto Piedade, Antonio Egidio Nardi, Sergio Machado, Pedro Ribeiro, Oscar Arias-carrión
"... It is well known that perception and estimation of time are fundamental for the relationship between humans and their environment. However, this temporal information processing is inefficient in patients with Parkinson ’ disease (PD), resulting in temporal judgment deficits. In general, the pathophy ..."
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It is well known that perception and estimation of time are fundamental for the relationship between humans and their environment. However, this temporal information processing is inefficient in patients with Parkinson ’ disease (PD), resulting in temporal judgment deficits. In general
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