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A Bayesian connectivitybased approach to constructing probabilistic gene regulatory networks
, 2004
"... Motivation: We have hypothesized that the construction of transcriptional regulatory networks using a method that optimizes connectivity would lead to regulation consistent with biological expectations. A key expectation is that the hypothetical networks should produce a few, very strong attractors, ..."
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Cited by 29 (14 self)
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Motivation: We have hypothesized that the construction of transcriptional regulatory networks using a method that optimizes connectivity would lead to regulation consistent with biological expectations. A key expectation is that the hypothetical networks should produce a few, very strong attractors
unknown title
, 2004
"... BIOINFORMATICS Vol. 20 no. 17 2004, pages 2918–2927doi:10.1093/bioinformatics/bth318 A Bayesian connectivitybased approach to constructing probabilistic gene regulatory networks ..."
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BIOINFORMATICS Vol. 20 no. 17 2004, pages 2918–2927doi:10.1093/bioinformatics/bth318 A Bayesian connectivitybased approach to constructing probabilistic gene regulatory networks
A Bayesian method for the induction of probabilistic networks from data
 MACHINE LEARNING
, 1992
"... This paper presents a Bayesian method for constructing probabilistic networks from databases. In particular, we focus on constructing Bayesian belief networks. Potential applications include computerassisted hypothesis testing, automated scientific discovery, and automated construction of probabili ..."
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Cited by 1381 (32 self)
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This paper presents a Bayesian method for constructing probabilistic networks from databases. In particular, we focus on constructing Bayesian belief networks. Potential applications include computerassisted hypothesis testing, automated scientific discovery, and automated construction
Bayesian Network Classifiers
, 1997
"... Recent work in supervised learning has shown that a surprisingly simple Bayesian classifier with strong assumptions of independence among features, called naive Bayes, is competitive with stateoftheart classifiers such as C4.5. This fact raises the question of whether a classifier with less restr ..."
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Cited by 788 (23 self)
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restrictive assumptions can perform even better. In this paper we evaluate approaches for inducing classifiers from data, based on the theory of learning Bayesian networks. These networks are factored representations of probability distributions that generalize the naive Bayesian classifier and explicitly
Learning probabilistic relational models
 In IJCAI
, 1999
"... A large portion of realworld data is stored in commercial relational database systems. In contrast, most statistical learning methods work only with "flat " data representations. Thus, to apply these methods, we are forced to convert our data into a flat form, thereby losing much ..."
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Cited by 619 (31 self)
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objects. Although PRMs are significantly more expressive than standard models, such as Bayesian networks, we show how to extend wellknown statistical methods for learning Bayesian networks to learn these models. We describe both parameter estimation and structure learning — the automatic induction
Modeling and simulation of genetic regulatory systems: A literature review
 JOURNAL OF COMPUTATIONAL BIOLOGY
, 2002
"... In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between ..."
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Cited by 729 (15 self)
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DNA, RNA, proteins, and small molecules. As most genetic regulatory networks of interest involve many components connected through interlocking positive and negative feedback loops, an intuitive understanding of their dynamics is hard to obtain. As a consequence, formal methods and computer tools
A Practical Bayesian Framework for Backprop Networks
 Neural Computation
, 1991
"... A quantitative and practical Bayesian framework is described for learning of mappings in feedforward networks. The framework makes possible: (1) objective comparisons between solutions using alternative network architectures ..."
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Cited by 496 (20 self)
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A quantitative and practical Bayesian framework is described for learning of mappings in feedforward networks. The framework makes possible: (1) objective comparisons between solutions using alternative network architectures
Probabilistic Principal Component Analysis
 Journal of the Royal Statistical Society, Series B
, 1999
"... Principal component analysis (PCA) is a ubiquitous technique for data analysis and processing, but one which is not based upon a probability model. In this paper we demonstrate how the principal axes of a set of observed data vectors may be determined through maximumlikelihood estimation of paramet ..."
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Cited by 703 (5 self)
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of parameters in a latent variable model closely related to factor analysis. We consider the properties of the associated likelihood function, giving an EM algorithm for estimating the principal subspace iteratively, and discuss, with illustrative examples, the advantages conveyed by this probabilistic approach
Probabilistic Visual Learning for Object Representation
, 1996
"... We present an unsupervised technique for visual learning which is based on density estimation in highdimensional spaces using an eigenspace decomposition. Two types of density estimates are derived for modeling the training data: a multivariate Gaussian (for unimodal distributions) and a Mixtureof ..."
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Cited by 705 (15 self)
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We present an unsupervised technique for visual learning which is based on density estimation in highdimensional spaces using an eigenspace decomposition. Two types of density estimates are derived for modeling the training data: a multivariate Gaussian (for unimodal distributions) and a Mixture
Mixtures of Probabilistic Principal Component Analysers
, 1998
"... Principal component analysis (PCA) is one of the most popular techniques for processing, compressing and visualising data, although its effectiveness is limited by its global linearity. While nonlinear variants of PCA have been proposed, an alternative paradigm is to capture data complexity by a com ..."
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Cited by 537 (6 self)
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maximumlikelihood framework, based on a specific form of Gaussian latent variable model. This leads to a welldefined mixture model for probabilistic principal component analysers, whose parameters can be determined using an EM algorithm. We discuss the advantages of this model in the context
Results 1  10
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351,627