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2009

by Carlo Visco , Alexander Tzankov , Zijun Y Xu-Monette , Roberto N Miranda , Yu Chuan Tai , Yan Li , Wei-Min Liu , Emanuele S G D'amore , Yong Li , Santiago Montes-Moreno , Karen Dybkaer , April Chiu , Attilio Orazi , Youli Zu , Govind Bhagat , Huan-You Wang , Cherie H Dunphy , Eric D His , X Frank Zhao , William Wl Choi , Xiaoying Zhao , J Han Van Krieken , Qin Huang , Weiyun Ai , Stacey O'neill , Maurilio Ponzoni , Andres Jm Ferreri , Brad S Kahl , Jane N Winter , Ronald S Go , Stephan Dirnhofer , Miguel A Piris , Michael B Møller , Lin Wu , L Jeffrey Medeiros , Ken H Young
"... ABSTRACT © F e r r a t a S t o r t i F o u n d a t i o n BCL2 translocations are more frequently found in the GCB subtype, whereas 18q21 locus amplification is more common in the ABC subtype of DLBCL. 3, Design and Methods Patients We studied 327 cases of previously untreated de novo DLBCL, diagnos ..."
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Review Board at The University of Texas MD Anderson Cancer Center in Houston, Texas, USA. Immunohistochemistry for Bcl-2 and cut-off determination Bcl-2 protein expression was evaluated in all patients using a monoclonal anti-Bcl-2 antibody (Clone-124, Dako, Carpinteria, CA, USA) and standard

2009

by Joachim B Kunz , Tobias Rausch , Obul R Bandapalli , Juliane Eilers , Paulina Pechanska , Stephanie Schuessele , Yassen Assenov , Adrian M Stütz , Renate Kirschner-Schwabe , Jana Hof , Cornelia Eckert , Arend Von Stackelberg , Martin Schrappe , Martin Stanulla , Rolf Koehler , Smadar Avigad , Sarah Elitzur , Rupert Handgretinger , Vladimir Benes , Joachim Weischenfeldt , Jan O Korbel , Martina U Muckenthaler , Andreas E Kulozik , 2015
"... Relapsed precursor T-cell acute lymphoblastic leukemia is characterized by resistance against chemotherapy and is frequently fatal. We aimed at understanding the molecular mechanisms resulting in relapse of T-cell acute lymphoblastic leukemia and analyzed 13 patients at first diagnosis, remission a ..."
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the primary leukemia whereas 'type 2' relapse originates from a common pre-leukemic ancestor. Relapse-specific changes included activation of the nucleotidase NT5C2 resulting in resistance to chemotherapy and mutations of epigenetic modulators, exemplified by SUZ12, WHSC1 and SMARCA4. While

2009

by Schafiq Nabhani , Sebastian Ginzel , Hagit Miskin , Shoshana Revel-Vilk , Dan Harlev , Bernhard Fleckenstein , Andrea Hönscheid , Prasad T Oommen , Michaela Kuhlen , Ralf Thiele , Hans-Jürgen Laws , Arndt Borkhardt , Polina Stepensky , Ute Fischer , 2015
"... ABSTRACT © F e r r a t a S t o r t i F o u n d a t i o n For instance, forced expression of the Fas regulating miR146a caused an immune disorder similar to ALPS in transgenic mice. Methods Study cohorts and DNA isolation Twenty-six ALPS patients, relatives and healthy controls were enrolled in the ..."
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's lymphocytes to test for IL12RB1 expression on the cell surface. To this end, primary lymphocytes from the patient and healthy individuals were stimulated for 4 days with phytohemagglutinin/IL2. Whereas lympho- + cells specifically induced in IL12-treated compared to untreated cells is shown. (C) Cultivated

2009

by Constance C F M J Baaten , Leo F Veenstra , Rick Wetzels , Johanna P Van Geffen , Frauke Swieringa , Susanne M De Witt , Yvonne M C Henskens , Harry Crijns , Sven Nylander , J J J Van Giezen , Johan W M Heemskerk , Paola E J Van Der Meijden , 2015
"... ABSTRACT © F e r r a t a S t o r t i F o u n d a t i o n function of platelets recovers after discontinuation of prasugrel treatment. We hypothesized an immediate recovery of newly formed, juvenile platelets to the level of untreated platelets. Our data provide evidence for a critical role of the j ..."
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was collected on the last treatment day, and at 1, 2, 5 and 30 days later. From 2 patients, blood samples were also collected after 12 days to better understand the delayed regain of platelet function. Patients with a malignancy, active infection or a known platelet disorder were not included. Blood

2009

by unknown authors , 2013
"... ARTICLES 305 Thalassemia Syndromes Introduction A growing number of studies describe BCL11A as a major repressor of fetal hemoglobin (HbF) expression. These include the description of several single nucleotide polymorphisms (SNPs) located in the BCL11A gene and linked to HbF level, and thus, the se ..."
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-ANT II™; Bio-Rad Laboratories, Hercules, CA, USA). The molecular analysis of the b-globin cluster was achieved including deletion detection using the quantitative multiplex polymerase chain reaction of short fragment (QMPSF) procedure. 9 Precise localization of unknown breakpoints was determined using a

2009

by Neil A Goldenberg , Timothy J Bernard , Jasper Hillhouse , Jennifer Armstrong-Wells , Jeffrey Galinkin , Rhonda Knapp-Clevenger , Linda Jacobson , Santica M Marcovina , Marilyn J Manco-Johnson , 2013
"... Lipoprotein (a) is a risk factor for adult cardiovascular events, in which the apolipoprotein (a) component is thought to promote atherogenesis and impair fibrinolysis. We investigated whether elevated plasma lipoprotein (a) concentration and small predominant apolipoprotein (a) isoform size (numbe ..."
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and laboratory determinations. Cases were followed for recurrence in a prospective cohort study. The median lipoprotein (a) concentration did not differ between groups [cases: median 18.0 nmol/L (7.5 mg/dL) and observed range 0.9-259 nmol/L (0.38-108.0 mg/dL), controls: 20.4 nmol/L (8.5 mg/dL) and 0.2-282 nmol

2009

by David Gonzalez , Monica Else , Dorte Wren , Monica Usai , Anne Mette Buhl , Anton Parker , David Oscier , Gareth Morgan , Daniel Catovsky
"... Articles Chronic Lymphocytic Leukemia 274 haematologica | 2013; 98(2) Introduction Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a highly variable outcome depending on clinical and biological characteristics. Clinical staging is a relatively simple method of assessing the outco ..."
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the outcome of CLL patients based on clinical parameters. 1,2 In the last two decades, multiple biological markers have been shown to have prognostic relevance in CLL, most notably chromosomal aberrations, IGHV mutations and expression of surface markers such as ZAP-70 and CD38. Design and Methods Patients

2009

by Jasmijn D E De Rooij , Eva Beuling , Marry M Van Den Heuvel-Eibrink , Askar Obulkasim , André Baruchel , Jan Trka , Dirk Reinhardt , Edwin Sonneveld , Brenda E S Gibson , Rob Pieters , Martin Zimmermann , C Michel Zwaan , † , Maarten Fornerod , 2015
"... ABSTRACT © F e r r a t a S t o r t i F o u n d a t i o n by controlling transcriptional regulators, such as GATA1 and RUNX1. Methods Patients' samples Samples were provided by the Dutch Childhood Oncology Group (DCOG, the Netherlands), the AML-Berliner-FrankfurtMünster Study Group (Germany an ..."
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and focal IKZF1-deleted cases Loss of IKZF1 function, a well-known tumor-inducing event in ALL, is conceivably one of the reasons for the recurrent heterozygous loss of chromosome 7, as this would include losing the IKZF1 locus on 7p12.2. We hypothesized that, if loss of IKZF1 were to be one of the driving

2009

by Hideki Nakasone , Mats Remberger , Lu Tian , Petter Brodin , Bita Sahaf , Fang Wu , Jonas Mattsson , Robert Lowsky , Robert Negrin , David B Miklos , Everett Meyer , 2015
"... Sex-mismatched hematopoietic cell transplantation is linked to increased graft-versus-host disease and mortality in myeloablative conditioning. Here we evaluated outcomes of 1,041 adult transplant recipients at two centers between 2006 and 2013 and investigated how the effect of sex-mismatching dif ..."
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significant. All analyses and data management were performed using Stata version 12.0 (StataCorp, College Station, TX, USA), and EZR. 23 Results Patients' characteristics In general, conditioning intensity is selected based on patients' characteristics, such as age and co-morbidity, and donor

2001; 12

by Luz Muñoz , Josep F Nomdedéu , Olga López , MAR BELLIDO Maria J Carnicer , Anna Aventín , Salut Brunet , Jorge Sierra , MD Josep F Nomdedéu , Laboratori D'hematologia , Mikimos
"... acute leukemia. CD123 is expressed with a characteristic pattern in cases of hairy cell leukemia. ©2001, Ferrata Storti Foundation Key words: acute leukemia, B-cell lymphoproliferative disorders, CD123 expression, IL-3 receptor α chain, hairy cell leukemia, minimal residual disease. © F e r r a t a ..."
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), CD14 (M0P9 FITC), CD3 (SK7 PerCp), CD4 (Leu 3 FITC), CD5 (Leu 1 FITC), CD8 (Leu 2 PE) purchased from Becton Dickinson, San José, CA, USA (BDIS); CD19 (SJ25-C1 PE/Cy 5) and MPO (H-43-5 FITC) from Caltag Laboratories, Burlingame, CA, USA; CD 123 (9F5 PE), CD10 (HI10a, Cy-Chrome) from Pharmingen, San
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Results 1 - 10 of 152
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