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TILLING- a shortcut in functional genomics

by Plant Genetics Review, Marzena Kurowska, Agata Daszkowska-golec, Iwona Szarejko, Miroslaw Maluszynski
"... Abstract Recent advances in large-scale genome sequencing projects have opened up new possibilities for the application of conventional mutation techniques in not only forward but also reverse genetics strategies. TILLING (Targeting Induced Local Lesions IN Genomes) was developed a decade ago as an ..."
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Abstract Recent advances in large-scale genome sequencing projects have opened up new possibilities for the application of conventional mutation techniques in not only forward but also reverse genetics strategies. TILLING (Targeting Induced Local Lesions IN Genomes) was developed a decade ago

Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet

by John Kuchtey, Lana M. Olson, Tommy Rinkoski, Edward O. Mackay, T. M. Iverson, Kirk N, Jonathan L. Haines, Rachel W. Kuchtey
"... Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide, with elevated intraocular pressure as an important risk factor. Increased resistance to outflow of aqueous humor through the trabecular meshwork causes elevated intraocular pressure, but the specific mechanisms are unknown ..."
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are unknown. In this study, we used genome-wide SNP arrays to map the disease gene in a colony of Beagle dogs with inherited POAG to within a single 4 Mb locus on canine chromosome 20. The Beagle POAG locus is syntenic to a previously mapped human quantitative trait locus for intraocular pressure on human

Enhancing Genetic Gains from Breeding

by unknown authors
"... Maize is an important crop for food, feed, forage, and fuel across tropical and temperate areas of the world. Diversity studies at genetic, molecular, and functional levels have revealed that, tropical maize germplasm, landraces, and wild relatives harbor a significantly wider range of genetic varia ..."
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variation. Among all types of markers, SNP markers are increasingly the marker-of-choice for all genomics applications in maize breeding. Genetic mapping has been developed through conventional linkage mapping and more recently through linkage disequilibrium-based association analyses. Maize genome

Enhancing Genetic Gains from Breeding

by unknown authors
"... Maize is an important crop for food, feed, forage, and fuel across tropical and temperate areas of the world. Diversity studies at genetic, molecular, and functional levels have revealed that, tropical maize germplasm, landraces, and wild relatives harbor a significantly wider range of genetic varia ..."
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variation. Among all types of markers, SNP markers are increasingly the marker-of-choice for all genomics applications in maize breeding. Genetic mapping has been developed through conventional linkage mapping and more recently through linkage disequilibrium-based association analyses. Maize genome

Identification and Management of Loss of Function Alleles 1

by A L Van Eenennaam , J F Taylor , D S Brown , M F Smith , R D Schnabel , S E Poock , J E Decker , F D Dailey , M M Rolf , B P Kinghorn , M D Macneil , D J Patterson
"... Abstract This paper defines some of the scientific terms used when discussing genetic conditions, and reviews the genetic implications and consequences of mating individuals with various genotypes. Many genetic defects are recessive, and the reason for this is that mutant alleles often render the r ..."
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's with excellent genetic merit carry more deleterious alleles, it is because such sires are more likely to be represented on both sides of a pedigree opening up the possibility that an animal will inherit a deleterious allele from both its sire and dam. With the advent of genomic sequencing technologies, our

RESEARCH ARTICLE Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

by Abraham L. Brass, Derek M. Dykxhoorn, Yair Benita, Nan Yan, Alan Engelman, Ramnik J. Xavier, Judy Lieberman, Stephen J. Elledge
"... HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs). These proteins participate in a broad array of cellular functions and implicate new p ..."
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HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs). These proteins participate in a broad array of cellular functions and implicate new

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

by Ramnik J. Xavier, Judy Lieberman, Stephen J. Elledge
"... HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs). These proteins participate in a broad array of cellular functions and implicate new p ..."
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HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs). These proteins participate in a broad array of cellular functions and implicate new

CORRESPONDENCE Chemical genetics: reshaping biology through chemistry

by Thomas U. Mayer
"... To understand biological processes, biologists typically study how perturbations of protein functions affect the phenotype. Protein activity in living cells can be influenced in many different ways: by manipulation of the genomic information, by injecting inhibitory antibodies, or, more recently, by ..."
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and the classic genetic approach, where manipulations at the gene level are used to draw conclusions about the function of the corresponding protein. Chemical genetics has only recently been used as a systematic approach in biology. The term was coined in the 1990's, when combinatorial chemistry

RESEARCH ARTICLE Open Access Joint

by unknown authors
"... eQTL assessment of mater tissue from individu id nd polymorphisms that affect the expression level of a gene. A variety of methods are commonly used to detect result of gene expression analysis often depends strongly on the type of tissue examined for any given Lock et al. BMC Genomics (2015) 16:11 ..."
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differences in biological function and risk for disease. experiment, and this too is applicable to the identifica-tion of eQTLs. The study of tissue-by-tissue variation is an ongoing and dynamic area of research. In particu-lar, the Genotype-Tissue Expression (GTEx) project [4] is a large-scale collaborative

Genomic Sequence around Butterfly Wing Development Genes: Annotation and Comparative Analysis

by Inês C. Conceição, Anthony D. Long, Jonathan D. Gruber, Patrícia Beldade
"... Background: Analysis of genomic sequence allows characterization of genome content and organization, and access beyond gene-coding regions for identification of functional elements. BAC libraries, where relatively large genomic regions are made readily available, are especially useful for species wi ..."
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Background: Analysis of genomic sequence allows characterization of genome content and organization, and access beyond gene-coding regions for identification of functional elements. BAC libraries, where relatively large genomic regions are made readily available, are especially useful for species
Results 11 - 20 of 75