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75
From Boolean to Probabilistic Boolean Networks as Models of Genetic Regulatory Networks
- Proc. IEEE
, 2002
"... Mathematical and computational modeling of genetic regulatory networks promises to uncover the fundamental principles governing biological systems in an integrarive and holistic manner. It also paves the way toward the development of systematic approaches for effective therapeutic intervention in di ..."
Abstract
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Cited by 124 (23 self)
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in disease. The central theme in this paper is the Boolean formalism as a building block for modeling complex, large-scale, and dynamical networks of genetic interactions. We discuss the goals of modeling genetic networks as well as the data requirements. The Boolean formalism is justified from several
Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana.
- Nat. Biotechnol.
, 2010
"... We introduce a rational approach for associating genes with plant traits by combined use of a genome-scale functional network and targeted reverse genetic screening. We present a probabilistic network (AraNet) of functional associations among 19,647 (73%) genes of the reference flowering plant Arab ..."
Abstract
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Cited by 45 (10 self)
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We introduce a rational approach for associating genes with plant traits by combined use of a genome-scale functional network and targeted reverse genetic screening. We present a probabilistic network (AraNet) of functional associations among 19,647 (73%) genes of the reference flowering plant
Large-scale analysis of tandem repeat variability in the human genome
, 2013
"... Tandem repeats are short DNA sequences that are re-peated head-to-tail with a propensity to be variable. They constitute a significant proportion of the hu-man genome, also occurring within coding and reg-ulatory regions. Variation in these repeats can alter the function and/or expression of genes a ..."
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Tandem repeats are short DNA sequences that are re-peated head-to-tail with a propensity to be variable. They constitute a significant proportion of the hu-man genome, also occurring within coding and reg-ulatory regions. Variation in these repeats can alter the function and/or expression of genes
Gene-environment interaction and the genetics of depression
- J Psychiatry Neurosci
, 2004
"... Depression is a group of brain disorders with varied origins, complex genetics and obscure neurobiology. Definitions of clinical phenotypes are not rooted in their neurobiology, and animal models of behavioural despair have considerable limitations. Nevertheless, investigation of subtle alterations ..."
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Cited by 4 (0 self)
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and hyporesponsivity of 5HT 1A receptors in patients with major depression are not reversed by antidepressant drug treatment, 59-61 thus further supporting the notion that low receptor function is a trait and, therefore, a pathogenetic mechanism of the disease. Gene-expression profiling Large-scale, high-throughput, c
Genetics and genomics of behavioral and psychiatric disorders Molecular and Human Genetics, and
"... Psychiatric conditions are to some degree under genetic influences. Despite the application of advanced genetic and molecular biological technologies, the genetic bases of the human behavioral traits and psychiatric diseases remains largely unresolved. Conventional genetic linkage approaches have n ..."
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. The approaches include using families in which specific behaviors segregate as a mendelian trait, utilization of endophenotypes as biological intermediate traits, identification of psychiatric disease phenotypes in genomic disorders, and the establishment of mouse models. Rare families in which behavioral
Systematic Genetic Analysis Identifies Cis-eQTL Target Genes Associated with Glioblastoma Patient Survival
, 2014
"... Prior expression quantitative trait locus (eQTL) studies have demonstrated heritable variation determining differences in gene expression. The majority of eQTL studies were based on cell lines and normal tissues. We performed cis-eQTL analysis using glioblastoma multiforme (GBM) data sets obtained f ..."
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from The Cancer Genome Atlas (TCGA) to systematically investigate germline variation’s contribution to tumor gene expression levels. We identified 985 significant cis-eQTL associations (FDR,0.05) mapped to 978 SNP loci and 159 unique genes. Approximately 57 % of these eQTLs have been previously linked
RESEARCH ARTICLE Open Access
"... Genetic control of functional traits related to photosynthesis and water use efficiency in Pinus pinaster Ait. drought response: integration of genome annotation, allele association and QTL detection for candidate gene identification ..."
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Genetic control of functional traits related to photosynthesis and water use efficiency in Pinus pinaster Ait. drought response: integration of genome annotation, allele association and QTL detection for candidate gene identification
© American Dairy Science Association, 2008. A Whole-Genome Scan to Map Quantitative Trait Loci for Conformation and Functional Traits in Canadian Holstein Bulls
, 2007
"... Genetic improvement of livestock populations can be achieved through detection and mapping of genetic markers linked to quantitative trait loci (QTL). With the completion of the bovine genome sequence assembly, single nucleotide polymorphism (SNP) assays spanning the whole bovine genome and research ..."
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and research work on large-scale identification, validation, and analysis of genotypic variation in cattle has become possible. A total of 462 Canadian Holstein Bulls were used to test the association between SNP and QTL. Single locus linkage disequilibrium regression model was implemented to perform a whole
Article number: 48 NEWS AND VIEWS Systematic genetics swims forward elegantly
, 2006
"... Sometimes when two (or more) genes are perturbed simultaneously, the organism exhibits a surprising property. This property may be a phenotype—either qualitative or quantitative—or the penetrance of a phenotype. This phenomenon, called genetic interaction, suggests that the interacting genes have re ..."
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the feeding approach in C. elegans, Ahringer and coworkers (Kamath et al, 2003) performed the first genome-scale RNAi screen. Large-scale RNAi screens have since been performed in cultured fly and mammalian cells. Genetic interactions can be tested by performing such an RNAi screen in the presence and absence
A Rapid DNA Mini-prep Method for Large-Scale Rice Mutant Screening
, 2006
"... Abstract: A high throughput rice DNA mini-preparation method was developed. The method is suitable for large-scale mutant bank screening as well as large mapping populations with characteristics of maintaining relatively high level of DNA purity and concentration. The extracted DNA was tested and s ..."
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shifted from sequence analysis (genomics) to identifying and understanding the functions (functional genomics) of nearly 40 000 genes presented in rice genome [ 1 -3 ] . Gene functional identification requires new materials and methods. Mutant is considered as one of the most important sources
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