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Adhesion molecules of cultured hematopoietic malignancies . A calcium-dependent lectin is the principle mediator of binding to the high endothelial venule of lymph nodes
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"... This study documents that a calcium-dependent phosphoman-nosyl-binding site on human lymphoid malignancies mediates attachment to the peripheral node high endothelial venule (PNHEV). The phorbol ester PMA coordinately upregulates lectin activity and binding to the PNHEV in the human T-lym-phoblastic ..."
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-lym-phoblastic cell line Jurkat but not in the less phenotypically mature lines HSB2, Molt4, CEM, and HPB-ALL. In contrast, expression of CD18, CD2, and several common epitopes of the putative adhesion receptor gp90fIerme (CD44) did not correlate with attachment to PNHEV in this series of cell lines. Insensi
RESEARCH ARTICLE Genetic (co)variance of ra d t
"... uniformity, especially the sign and magnitude of its rg. Ge n e t i c s Se lec t ion Evolut ion Sae-Lim et al. Genetics Selection Evolution (2015) 47:46 DOI 10.1186/s12711-015-0122-8practice to reduce heterogeneity in growth performance isJokioinen, FinlandFull list of author information is availabl ..."
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variance for a trait [4-6]. Accordingly, less sensitive genotypes have offspring that are more uniform and show a smaller within-family residual variance. In animal production, uniformity is often a desired character because: (1) it indicates pheno-typic robustness and (2) it aids in producing homogeneous
Frequency of CFTR, SPINK1, and Cathepsin B Gene Mutation in North Indian Population: Connections between Genetics and Clinical Data
"... Objectives. Genetic mutations and polymorphisms have been correlated with chronic pancreatitis (CP). This study aims to investigate the association of genetic variants of cystic fibrosis transmembrane conductance regulator (CFTR) and serine protease inhibitor Kazal type 1 (SPINK-1) genes and Cathep ..."
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and Cathepsin B gene polymorphisms with CP and to associate genetic backgrounds with clinical phenotypes. Methods. 150 CP patients and 150 normal controls were enrolled consecutively. We analyzed SPINK-1 N34S and IVS3+2T>C gene mutations by PCR-restriction-fragment length polymorphism (RFLP
Research Article Frequency of CFTR, SPINK1, and Cathepsin B Gene Mutation in North Indian Population: Connections between Genetics and Clinical Data
"... Copyright © 2014 Shweta Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. Genetic mutations and polymorphisms ..."
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genetic backgrounds with clinical phenotypes. Methods. 150 CP patients and 150 normal controls were enrolled consecutively. We analyzed SPINK-1 N34S and IVS3+2T>C gene mutations by PCR-restriction-fragment length polymorphism (RFLP). The identification of DF508, G551D, G542X, R117H, and W1282X
CONFERENCE PAPER Growth factor receptor
"... r r yp de lec ien revealing that despite the anti-EGFR agents demonstrating some anti-tumour activity, there is a high level of de novo and acquired resistance to such treatments and moreover, overexpression of consequently, poor patient outlook. (Nicholson et al. EGFR might result in the restoratio ..."
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r r yp de lec ien revealing that despite the anti-EGFR agents demonstrating some anti-tumour activity, there is a high level of de novo and acquired resistance to such treatments and moreover, overexpression of consequently, poor patient outlook. (Nicholson et al. EGFR might result
VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis
"... Introduction VEGFR-3 is a member of the VEGFR receptor tyrosine kinase family. It is expressed on lymphatic endothelial cells (LECs) and plays a central role in the regulation of lymphangiogenesis. 1 On binding to its ligands, VEGF-C and VEGF-D, VEGFR-3 is activated and orchestrates the outgrowth o ..."
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% penicillin-streptomycin. Differentiation was induced with 10nM tetradecanoyl phorbol acetate (TPA; Sigma-Aldrich). Primary human microvascular LECs (Cambrex) from the dermis (HMVECdLyNeo) were cultivated in EGM-2MV (Lonza) and 5% FCS supplemented with growth factors provided by the manufacturer. Bovine