Reference 1. Please contact Dr. C. Keith Paulson, Senior Technical Manager, Mitsubishi Nuclear Energy Systems, Inc. if the NRC has questions concerning any aspect of the submittals. His contact information is below. Sincerely, Yoshiki Ogata,

Representations of linguistic information and the neural substrates that underlie them are incredibly complex. This chapter illustrates how connectionist modeling has furthered our understanding of normal and impaired processing in three related domains – semantic memory, knowledge of grammatical

Chronic inflammation and pro-inflammatory cytokines as well as T helper type 2 (TH2) cytokines have been involved in the pathogenesis of pulmonary injury and lung fibrosis. The actual role of IL-10 in lung fibrosis is still unclear because this cytokine has been identified as TH2 but possesses strong anti-inflammatory properties. To better dissect the potential role of IL-10 in silica-induced lung fibrosis, IL-10 was overexpressed in the lung of mice by adenoviral gene transfer during the inflammatory (administered at d-1) or the fibrotic (administered at d+30) stages of the disease. Pulmonary overexpression of IL-10 during both silica-induced lung inflammation and fibrosis exacerbated the fibrotic lesions as estimated by the measurement of hydroxyproline, and other biochemical and histological markers. Increased expression of IL-10 significantly enhanced the number of lung lymphocytes and BALF IgG1 but not IgG2a levels, indicating the induction of a TH2-like immune response. In addition, the production of the pro-fibrotic TH2 cytokines IL-4 and IL-13 was also significantly increased upon IL-10 overexpression. No difference in TGF- or PGE2 production was noted after AdIL-10 treatment of silica-treated mice. Together, these data

Propagating waves during cortical cholinergic oscillations JN-00715-2002.R2 Neocortical “theta ” oscillation (5- 12 Hz) has been observed in animals and human subjects but little is known about how the oscillation is organized in the cortical intrinsic networks. Here we use voltage-sensitive dye and optical imaging to study a carbachol/bicuculline induced theta (~8 Hz) oscillation in rat neocortical slices. The imaging has large signal-to-noise ratio, allowing us to map the phase distribution over the neocortical tissue during the oscillation. The oscillation was organized as spontaneous epochs and each epoch was composed of a “first spike”, a “regular ” period (with relatively stable frequency and amplitude) and an “irregular ” period (with variable frequency and amplitude) of oscillations. During each cycle of the regular oscillation one wave of activation propagated horizontally (parallel to the cortical lamina) across the cortical section at a velocity of ~50 mm/sec. Vertically the activity was synchronized through all cortical layers. This pattern of one propagating wave associated with one oscillation cycle was seen during all the regular cycles. The oscillation frequency varied noticeably at two

In this study we present a non-invasive method which enables the investigation of the Fetal Heart Rate (FHR) fluctuations. The objective was to design a quantitative measurement to assess the fetal Autonomic Nervous System (ANS) and to investigate its development as a function of the gestational age. Our Medical Physics group has developed a complex algorithm for on-line beat-to-beat detection of the Fetal ECG (FECG), extracted from the maternal abdominal ECG signal. We used our previously acquired FECG data which includes non-invasive recordings of 200 maternal abdominal ECG signals. From these, we chose 35 cases of healthy pregnancies which we divided into three groups according to gestational age: Group 1-23±2 weeks, Group 2- 32±1 weeks, and Group 3- 39±1 weeks. The FHR Variability (FHRV) was analyzed by a time-frequency decomposition based on a Continuous Wavelet Transform (CWT). We have shown that independently of the gestational age most of the FHR power is concentrated in the Very Low Frequency (VLF) range (0.02-0.08Hz) and in the Low

The horizontal and vertical integration of the media processes, which was originally initiated by the rapid development in ICT technology, has resulted in a media convergence, where multiple media offer a new brand of information service. Therefore, the content must be stored in a structured form

www.cordio.org, www.cordioea.org Principal investigator or contact responsible for conducting the project: Innocent Wanyonyi Geographic coverage of the project: Western Indian Ocean countries within

A Preliminary Bibliography on Injection Drug Use and Users (IDU) in Canada. A work in progress: comments and additional references are welcome. Please forward to the contact below. Produced with financial support from the

The article has an online data supplement to the methods section, which is accessible from this issue’s table of content online at www.atsjournals.org. Inhalation of toxins commonly found in air pollution contributes to the development and progression of asthma and environmental airway injury. In this study, we investigated the requirement of tlr4 in mice for pulmonary responses to three environmental toxins: aerosolized lipopolysaccharide (LPS), particulate matter (residual oil fly ash or ROFA), and ozone. The physiologic and biologic responses to these toxins were evaluated by the extent of airway responsiveness, neutrophil recruitment to the lower respiratory tract, changes in inflammatory cytokines, and the concentration of protein in the lavage fluid. Genetically engineered, tlr4-deficient mice (C57BL/6 tlr4-/-) were unresponsive to inhaled LPS, except for minimal increases in some inflammatory cytokines. In contrast, C57BL/6 tlr4-/-mice did not differ from wild type mice in their airway

Abstract. Recently an effective technique has been introduced in graphics bibliography for simulating and rendering properly shaded fur, grass or similar textures using multiple layers of concentric textures. This paper is a guide to simple step-by-step modeling of furry objects with shadows that can be directly implemented either in standard rendering software or in rendering APIs for real time applications, without requiring specialized graphics hardware. 1.