Tools
Sorted by:
Try your query at:
 |
 |
 |
 |
 |
 |
Results 11 - 20
of
810
Antibodies Recognize Autoantigens and Induce Apoptosis of Pancreatic Beta Cells
"... Type 1 diabetes is characterized by autoimmune destruction of pancreatic beta cells. The role played by autoantibodies directed against beta cells antigens in the pathogenesis of the disease is still unclear. Coxsackievirus B infection has been linked to the onset of type 1 diabetes; however its pre ..."
Abstract
- Add to MetaCart
Type 1 diabetes is characterized by autoimmune destruction of pancreatic beta cells. The role played by autoantibodies directed against beta cells antigens in the pathogenesis of the disease is still unclear. Coxsackievirus B infection has been linked to the onset of type 1 diabetes; however its
Review Article Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes
, 2015
"... permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetes is a global health problem and a national economic burden. Although several antidiabetic drugs are available, the need for novel therapeutic agents with improved efficacy an ..."
Abstract
- Add to MetaCart
and few side effects remains. Drugs derived from natural compounds are more attractive than synthetic drugs because of their diversity and minimal side effects. This review summarizes the most relevant effects of various plant-derived natural compounds on the functionality of pancreatic beta cells
ARTICLE Multivesicular exocytosis in rat pancreatic beta cells
, 2011
"... Aims/hypothesis To establish the occurrence, modulation and functional significance of compound exocytosis in insulin-secreting beta cells. Methods Exocytosis was monitored in rat beta cells by electrophysiological, biochemical and optical methods. The functional assays were complemented by three-di ..."
Abstract
-
Cited by 1 (0 self)
- Add to MetaCart
Aims/hypothesis To establish the occurrence, modulation and functional significance of compound exocytosis in insulin-secreting beta cells. Methods Exocytosis was monitored in rat beta cells by electrophysiological, biochemical and optical methods. The functional assays were complemented by three
Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells*
"... The effects of a transient exposure to hydrogen peroxide (10 min at 200 �M H 2O 2) on pancreatic beta cell signal transduction and insulin secretion have been evaluated. In rat islets, insulin secretion evoked by glucose (16.7 mM) or by the mitochondrial substrate methyl succinate (5 mM) was markedl ..."
Abstract
- Add to MetaCart
The effects of a transient exposure to hydrogen peroxide (10 min at 200 �M H 2O 2) on pancreatic beta cell signal transduction and insulin secretion have been evaluated. In rat islets, insulin secretion evoked by glucose (16.7 mM) or by the mitochondrial substrate methyl succinate (5 m
Molecular Mechanism of
, 2010
"... by the mitogen-activated kinase DLK in pancreatic beta-cells ..."
The Effect of Glucose Fluctuation on Apoptosis and Function of INS-1 Pancreatic Beta Cells
"... Background: Blood glucose level continuously fluctuates within a certain range in the human body. In diabetes patients, the extent of such fluctuation is large, despite the strict control of blood glucose. Blood glucose fluctuation has been shown to mediate more adverse effects on vascular endotheli ..."
Abstract
- Add to MetaCart
endothelial cells and diabetes complications than chronic hyperglycemia, which has been explained as due to oxidative stress. As few previous studies have reported the effects of chronic and intermittent hyperglycemia on the apoptosis and function of pancreatic beta cells, this study reported herein
PARP-1 and YY1 Are Important Novel Regulators of CXCL12 Gene Transcription in Rat Pancreatic Beta Cells
"... Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact of CXCL12 expression on the pancreatic beta cell prosurvival pheno ..."
Abstract
- Add to MetaCart
Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact of CXCL12 expression on the pancreatic beta cell prosurvival
Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15
"... Glucose-dependent insulinotropic peptide (GIP) is an incretin hormone produced in the gastrointestinal tract that stimulates glucose dependent insulin secretion. Impaired incretin response has been documented in diabetic patients and was mainly related to the inability of the pancreatic beta cells ..."
Abstract
- Add to MetaCart
Glucose-dependent insulinotropic peptide (GIP) is an incretin hormone produced in the gastrointestinal tract that stimulates glucose dependent insulin secretion. Impaired incretin response has been documented in diabetic patients and was mainly related to the inability of the pancreatic beta cells
Results 11 - 20
of
810
