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Results 11 - 20
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30
5-HT1A gene promoter polymorphism and [ 18F]MPPF binding potential in healthy subjects: a PET
"... Background: Previous Positron Emission Tomography (PET) studies of 5-HT1A receptors have shown an influence of several genetic factors, including the triallelic serotonin transporter gene-linked polymorphic region on the binding potential (BPND) of these receptors. The aim of our study was to invest ..."
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Background: Previous Positron Emission Tomography (PET) studies of 5-HT1A receptors have shown an influence of several genetic factors, including the triallelic serotonin transporter gene-linked polymorphic region on the binding potential (BPND) of these receptors. The aim of our study
Brief Communication Reduced Serotonin Type 1 A Receptor Binding in Panic Disorder
, 2003
"... Recent animal models suggest that disturbances in serotonin type-1A receptor (5-HT1AR) function may contribute to chronic anxiety, although it is not clear at all whether such models constitute relevant models for panic disorder (PD) in humans. The selective 5-HT1AR radioligand [18F]trans-4-fluoro-N ..."
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Recent animal models suggest that disturbances in serotonin type-1A receptor (5-HT1AR) function may contribute to chronic anxiety, although it is not clear at all whether such models constitute relevant models for panic disorder (PD) in humans. The selective 5-HT1AR radioligand [18F]trans-4-fluoro
New PET Imaging Agent for the Serotonin Transporter: [18F]ACF (2-[(2-Amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine)
, 2002
"... A new F-18-labeled phenylthiophenyl derivative specific for imaging of serotonin transporters (SERT) in the brain by positron emission tomography (PET) is described. Fluorinated phenylthiophenyl derivative, ACF, 2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine, was prepared b ..."
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A new F-18-labeled phenylthiophenyl derivative specific for imaging of serotonin transporters (SERT) in the brain by positron emission tomography (PET) is described. Fluorinated phenylthiophenyl derivative, ACF, 2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine, was prepared
Quantitative Receptor-Based Imaging of Tumor Proliferation with the Sigma-2 Ligand [18F]ISO-1
"... The sigma-2 receptor is expressed in higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells, thus providing an attractive target for imaging the proliferative status (i.e., P:Q ratio) of solid tumors. Here we evaluate the utility of the sigma-2 receptor ligand 2-(2-[18F]flu ..."
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]fluoroethoxy)-N-(4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl)-5-methyl-benzamide, [18F]ISO-1, in two different rodent models of breast cancer. In the first study, small animal Positron Emission Tomography (PET) imaging studies were conducted with [18F]ISO-1 and 18FDG in xenografts of mouse mammary tumor
REVIEW ARTICLE Proton MR SpectroscopyDetectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications
"... between neurons and permit most neuronal-glial interactions in the CNS. Approximately 80 % of all neurons use glutamate, and almost all interneurons use GABA. A third neurotransmitter, NAAG, modulates glutamatergic neurotransmission. Concentration changes in these molecules due to defec-tive synthet ..."
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; EAAT excitatory amino acid transporter; EEG electro-encephalography; 18FDG-PET [18F]fluorodeoxyglucose–positron-emission tomography; GABA -aminobutyric acid; GLAST glutamate/aspartate transporter; 1H-MR proton MR; NAA
One-Pot Two-Step Radiosynthesis of a New 18F‑Labeled Thiol Reactive Prosthetic Group and Its Conjugate for Insulinoma Imaging
"... ABSTRACT: N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-ethyl)-6-fluoronicotinamide ([18F]FNEM), a novel prosthetic agent that is thiol-specific, was synthesized using a one-pot two-step strategy: (1) 18F incorporation by a nucleophilic displacement of trimethylammonium substrate under mild conditions ..."
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activity of 19−88 GBq/μmol (decay uncorrected). The in vitro cell uptake, in vivo biodistribution, and positron emission tomography (PET) imaging properties of its conjugation product with [Cys40]-exendin-4 were described. [18F]FNEM-Cys40-exendin-4 showed specific targeting of glucagon-like peptide 1
In Vivo Kinetics of [F-18]MEFWAY: A Comparison With [C-11]WAY100635 and [F-18]MPPF in the Nonhuman Primate
"... ABSTRACT [F-18]Mefway was developed to provide an F-18 labeled positron emis-sion tomography (PET) neuroligand with high affinity for the serotonin 5-HT1A receptor to improve the in vivo assessment of the 5-HT1A system. The goal of this work was to compare the in vivo kinetics of [F-18]mefway, [F-18 ..."
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ABSTRACT [F-18]Mefway was developed to provide an F-18 labeled positron emis-sion tomography (PET) neuroligand with high affinity for the serotonin 5-HT1A receptor to improve the in vivo assessment of the 5-HT1A system. The goal of this work was to compare the in vivo kinetics of [F-18]mefway, [F
Early Detection of Response to Experimental Chemotherapeutic Top216 with [ 18 F]FLT and [ 18 F]FDG PET in Human Ovary Cancer Xenografts in Mice
"... Background: 39-deoxy-39- [ 18 F]fluorothymidine ( 18 F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use 18 F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative eff ..."
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Background: 39-deoxy-39- [ 18 F]fluorothymidine ( 18 F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use 18 F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti
Initial evaluation in healthy humans of [ 18 F]DPA-714, a potential PET biomarker for neuroinflammation
"... Abstract Introduction: The translocator protein 18 kDa (TSPO), although minimally expressed in healthy brain, is up-regulated in pathological conditions, coinciding with microglial activation. It is thereby a suitable in vivo biomarker of neuroinflammation for detection, evaluation and therapeutic ..."
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Sv/MBq. Modeling of regional brain and plasma data showed good in vivo stability of [ 18 F]DPA-714 in humans, with only 20% of blood metabolites 20 min postinjection (p.i.). Maximum cerebral uptake was observed 5 min p.i., followed by two decreasing phases: a rapid washout (5-30 min) followed by a slower phase
Targeting Metal-Aβ Aggregates with Bifunctional Radioligand
"... ABSTRACT: Interest in quantifying metal-Aβ species in vivo led to the synthesis and evaluation of [11C]L2-b and [18F]FL2-b as radiopharmaceuticals for studying the metallobiology of Alzheimer’s disease (AD) using positron emission tomography (PET) imaging. [11C]L2-b was synthesized in 3.6 % radioche ..."
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ABSTRACT: Interest in quantifying metal-Aβ species in vivo led to the synthesis and evaluation of [11C]L2-b and [18F]FL2-b as radiopharmaceuticals for studying the metallobiology of Alzheimer’s disease (AD) using positron emission tomography (PET) imaging. [11C]L2-b was synthesized in 3
Results 11 - 20
of
30
