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Radiodefluorination of 3-Fluoro-5-(2-(2-[18F](fluoromethyl)- thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat B
, 2008
"... Metabotropic glutamate subtype-5 receptors (mGluR5) are impli-cated in several neuropsychiatric disorders. Positron emission tomography (PET) with a suitable radioligand may enable moni-toring of regional brain mGluR5 density before and during treat-ments. We have developed a new radioligand, 3-fluo ..."
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Metabotropic glutamate subtype-5 receptors (mGluR5) are impli-cated in several neuropsychiatric disorders. Positron emission tomography (PET) with a suitable radioligand may enable moni-toring of regional brain mGluR5 density before and during treat-ments. We have developed a new radioligand, 3
Radiosynthesis and Evaluation of an 18F‑Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu4)
"... ABSTRACT: Four 4-phthalimide derivatives of N-(3-chlorophenyl)-2-picolinamide were synthesized as potential ligands for the PET imaging of mGlu4 in the brain. Of these compounds, N-(3-chloro-4-(4-fluoro-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide (3, KALB001) exhibited improved binding affinity ..."
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.8% (n = 4), and the purity was over 98%. In vivo imaging studies in a monkey showed that the radiotracer quickly penetrated the brain with the highest accumulation in the brain areas known to express mGlu4. Despite some unfavorable radiotracer properties like fast washout in rodent studies, [18F]3
Metabolism of the a1 adenosine receptor positron emission tomography ligand [18f]8-cyclopentyl-3-(3-fluoropropyl)-1propylxanthine ([18f]cpfpx) in rodents and humans. Drug Metabol. Dispos
"... Studies of plasma from mice, rats, and human volunteers evalu-ated methods for the extraction and quantification of the positron emission tomography ligand [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX) and identification of its metabolites in plasma by thin-layer chromatography ..."
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Studies of plasma from mice, rats, and human volunteers evalu-ated methods for the extraction and quantification of the positron emission tomography ligand [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX) and identification of its metabolites in plasma by thin
Multidisciplinary Ophthalmic Imaging Positron Emission Tomography for the Development and Characterization of Corneal Permanence of Ophthalmic Pharmaceutical Formulations
"... Citation: Fernández-Ferreiro A, SilvaRodríguez J, Otero-Espinar FJ, et al. Positron emission tomography for the development and characterization of corneal permanence of ophthalmic pharmaceutical formulations. Invest Ophthalmol Vis Sci. 2017;58:772-780. DOI:10.1167/iovs.16-20766 PURPOSE. This wo ..."
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Citation: Fernández-Ferreiro A, SilvaRodríguez J, Otero-Espinar FJ, et al. Positron emission tomography for the development and characterization of corneal permanence of ophthalmic pharmaceutical formulations. Invest Ophthalmol Vis Sci. 2017;58:772-780. DOI:10.1167/iovs.16-20766 PURPOSE
Ga-Lissamine Rhodamine B (LRB) as a New Radiotracer for Imaging Tumors by Positron Emission Tomography
"... . Purpose. The aim of this study is to synthesize and evaluate 68 Ga-labeled Lissamine Rhodamine B (LRB) as a new radiotracer for imaging MDA-MB-231 and MCF-7 cells induced tumor mice by positron emission tomography (PET). Methods. Firstly, we performed the radio synthesis and microPET imaging of 6 ..."
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. Purpose. The aim of this study is to synthesize and evaluate 68 Ga-labeled Lissamine Rhodamine B (LRB) as a new radiotracer for imaging MDA-MB-231 and MCF-7 cells induced tumor mice by positron emission tomography (PET). Methods. Firstly, we performed the radio synthesis and microPET imaging
Positron Emission Tomographic Study of Suppression of Gray-Matter Glucose Utilization by Brain Tumors
"... Positron emission tomography (PET) scanning with [18F]-2-fluoro-2-deoxy-O-glucose (FOG) was used to study 59 patients w ith astrocytomas and three patients with other cerebral mass lesions. Suppression of gray-matter glucose utilization ranging from 8 % t o 64% (mean, 30% ) was seen in 92% of cases ..."
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metabolism of whole brai n or of systemic biochemical correlates of cerebral neopl asms lack neuroanatomic specifici ty. The recently developed technique of positron emission tomography (PET) using [18F]-2-fluoro-2-deoxy-0-glucose (FOG) provides a method of evaluating regiona l cerebral g lucose metaboli sm
doi:10.1155/2011/548123 Research Article Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [ 18 F]MK-9470
"... Copyright © 2011 Mathieu Verdurand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Despite the important role of cannabinoid C ..."
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emission tomography with [ 18 F]MK-9470. Analysis of covariance (ANCOVA) to control for body weight that would potentially influence [ 18 F]MK-9470 values between the two groups revealed a main effect of age (F(1, 109) = 5.0, P = 0.02) on [ 18 F]MK-9470 absolute binding (calculated as percentage
Imaging Brain Amyloid in Alzheimer’s
"... This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of associa ..."
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This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas
Interictal brain 5-HT1A receptors binding in migraine without aura: a 18F-MPPF-PET study
, 2008
"... In this study we aimed to assess the brain distribution of 5-HT1A receptors in migraine patients without aura. Ten female migraine patients and 24 female healthy volunteers underwent magnetic resonance imaging and positron emis-sion tomography using a radioligand antagonist of 5-HT1A receptors [4-(2 ..."
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In this study we aimed to assess the brain distribution of 5-HT1A receptors in migraine patients without aura. Ten female migraine patients and 24 female healthy volunteers underwent magnetic resonance imaging and positron emis-sion tomography using a radioligand antagonist of 5-HT1A receptors [4
ORIGINAL RESEARCH Open Access Evaluation of 18F-nifene binding to a4b2 nicotinic receptors in the rat brain using microPET imaging
"... MicroPET imaging studies using 18F-nifene, a new positron emission tomography (PET) radiotracer for nicotinic acetylcholinergic receptors (nAChR) a4b2 receptors in rats, have been carried out. Rats were imaged for 90 min after intravenous injection of 18F-nifene (0.8 to 1 mCi), and binding potential ..."
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MicroPET imaging studies using 18F-nifene, a new positron emission tomography (PET) radiotracer for nicotinic acetylcholinergic receptors (nAChR) a4b2 receptors in rats, have been carried out. Rats were imaged for 90 min after intravenous injection of 18F-nifene (0.8 to 1 mCi), and binding
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