"... In PAGE 45: ... Five large randomized trials published between 1989 and 1992 evaluated oral anticoagulation, and 2 tested aspirin for primary prevention of thromboembolism in patients with nonvalvular AF (32,456,468,469) (Fig. 16 and Table20 ). A sixth trial focused on secondary prevention among patients who had survived nondisabling stroke or transient cerebral ischemic attack (439).... In PAGE 46: ....5 to 4.0 and 2 to 3, respectively. These trials are summa- rized in Table20 . The duration of follow-up in these trials was generally between 1 and 2 years; the longest was 2.... ..."

"... In PAGE 3: ... Reciprocally, rCBF decrease was ob- served in several subcortical structures, including hip- pocampi and cerebellum. Correlations Between Neurocognitive Scores and Regional Cerebral Blood Flow Linear regressions between neuropsychological scores in the 13 explored domains and rCBF in the above- mentioned VOIs (with significant perfusion changes) are presented in Table3 . As an attempt at controlling for random correlations, only r-values H11350 0.... In PAGE 3: ... This finding may indicate that lower neuropsychological performance is associated with a rightward shift of cerebral perfusion, except for the motor speed task. We also noticed that left cerebellar rCBF decrease was interacting with the largest number of tests (see Table3 ), probably because this structure is involved in a wide range of functions. Discussion Our study demonstrates a lack of leftward cerebral per- fusion asymmetry in right-handed KS patients, further confirmed by a significant rCBF increase in many right-sided cortical regions, compared with controls.... In PAGE 5: ... Nonverbal functions were impaired to a lesser extent with relatively higher Z-scores, compared with verbal (see Table 1). Motor speed score was proportional to right parietal rCBF (see Table3 ), indicating that perfusion shift would be ambivalently associated with lower performance on ver- bal tasks and relatively higher performance on nonver- bal tasks. Such dissociation is thought to be more spe- cific in KS children than in adults.... ..."

"... In PAGE 42: ... Others, such as female gender, systolic blood pressure greater than 160 mmHg, and LV dysfunction, have been variably linked to stroke (163,167,442). The relative risk for ischemic stroke associ- ated with specific clinical features, derived from a collabo- rative analysis of participants given no antithrombotic ther- apy in the control groups of 5 randomized trials, is given in Table17 . Nearly half of AF-associated strokes occur in patients over age 75 years (Fig.... ..."

"... In PAGE 14: ... Atrial fibrillation is commonly encountered in patients with the sleep apnea syndrome, but whether the arrhythmia is provoked by hypoxia or other biochemical abnormality or mediated by changes in pulmo- nary dynamics or RA factors has not been determined. Table3 shows a list of associated heart diseases in the contemporary population of the ALFA study (21). 4.... ..."

"... In PAGE 3: ... with QRS duration greater than 130 ms were the had the highest prevalence of other ECG abnormal- (95%), and had the highest CV mortality. Table2 is comparison of the subsets of normal and ECGs and LBBB, RBBB, and paced rhythms. BBB and paced rhythm subsets tended to be older with QRS durations.... In PAGE 3: ...05 versus QRS duration less than 110 milliseconds. When patients without BBB or paced rhythms and pa- with BBB and paced rhythms were compared, the was noted: Annual mortality was highest in the group, followed by those with LBBB and RBBB Table2 ). Those with an abnormal ECG without BBB or rhythm had a lower annual mortality, and those with normal ECG had the lowest annual mortality.... ..."

"... In PAGE 3: ...egional cerebral blood flow rCBF increase vs. the comparison condition. b Regions of significant rCBF decrease. All regions shown are described in Table1 .... ..."

"... In PAGE 34: ... The dose of other medication used for rate control should be reduced approximately 6 weeks after initiation of amioda- rone and stopped if the rate slows excessively. Concomitant drug therapies ( Table10 ) should be monitored closely, and both the patient and the physician should be alert to possible deleterious drug interactions. 5.... ..."

"... In PAGE 40: ... CONCLUSIONS. A summary of recommendations for use of pharmacological agents to control the rate of ventricular response to AF is given in Table16 . A combination of drugs is often necessary to achieve rate control in AF patients in the acute and chronic settings.... ..."