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"... The introduction of human albumin micro spheres (HAM) is a significant advance in car rier-protein technology for the study of capil ..."
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The introduction of human albumin micro spheres (HAM) is a significant advance in car rier-protein technology for the study of capil
Inhibition of the action of nonsuppressible insulin-like activity on isolated rat fat cells by binding to its carrier protein
- J. Clin. Invest
, 1979
"... extracted and purified from human serum (NSILA-S) mimics all insulin-like effects in vitro and, after injec-tion, in vivo in the presence of excess insulin anti-bodies. However, there is no evidence that it exerts acute insulin-like effects in its native form in the cir-culation, where it is almost ..."
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Cited by 3 (0 self)
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completely bound to a specific large molecular weight carrier protein. In this paper we show that partially purified NSILA-S-car-rier protein, devoid ofendogenous insulin-like activity, inhibits the stimulatory effect of NSILA-S, but not of insulin, on 3-0-methylglucose transport and on lipo-genesis from [U
Towards a bottom-up modelling approach to the pancreatic β-cell electrophysiology
"... Glucose induced bursts of the membrane potential of pancreatic β-cells are at the origin of substantial intracellular calcium increases which, in turn, trig-ger exocytosis of insulin carrying vesicles. In the context of diabetes type II it is aimed to control vesicle exocytosis. This infers the nece ..."
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. In this contribution a method will be described that allows to include a max-imum of information about single transmembrane ion conducting molecules into the model [3]. The mostly measured characteristics of single channels and car-rier proteins are directly used and incorporated into a model in which only the protein
Drug carriers based on highly protein-resistant materials for prolonged in vivo circulation time
"... Long-circulating drug carriers are highly desirable in drug delivery system. However, nonspecific protein adsorption leaves a great challenge in drug delivery of intravenous administration and sig-nificantly affects both the pharmacokinetic profiles of the carrier and drugs, resulting in negatively ..."
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affect of therapeutic efficiency. Therefore, it is important to make surface modification of drug car-riers by protein-resistant materials to prolong the blood circulation time and increase the targeted accumulation of therapeutic agents. In this review, we highlight the possible mechanism of protein
Internalization-Associated Proteins among Streptococcus pyogenes Isolated from Asymptomatic Carriers and Children
, 2003
"... Sixty-two strains of Streptococcus pyogenes isolated from 30 asymptomatic school children and 32 children with pharyngitis were characterized to analyze the involvement of 2 fibronectin-binding proteins (F/SfbI and PrtF2/PfbpI) in S. pyogenes colonizing asymptomatic carriers and to determine the pos ..."
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/SfbI ( ) in both groups. These results suggest that the presence ofP!.001 the pfbpI gene can be linked to the ability of S. pyogenes to persist in the throat of asymptomatic carriers. Streptococcus pyogenes that colonizes asymptomatic car-riers does not cause acute disease but may enter a more quiescent state
HLA-restricted, Processing- and Metabolism-independent Pathway of Drug Recognition by Human
, 1591
"... T cell recognition of drugs is explained by the hapten-car-rier model, implying covalent binding of chemically reactive drugs to carrier proteins. However, most drugs are nonre-active and their recognition by T cells is unclear. We gen-erated T cell clones from allergic individuals specific to sul-f ..."
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T cell recognition of drugs is explained by the hapten-car-rier model, implying covalent binding of chemically reactive drugs to carrier proteins. However, most drugs are nonre-active and their recognition by T cells is unclear. We gen-erated T cell clones from allergic individuals specific to sul
302 ANNALS NEW YORK ACADEMY OF SCIENCES
"... ABSTRACT: We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity. The availability of biological sam-ples from various population cohorts in Denmark has given us the op-portunity to try novel ..."
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methods of gene association with human longevity. A significant association of one haplotype with male longevity was ob-served. Furthermore, a significant difference in the survival of the car-riers of the different genotypes in females was observed. We also found an age-dependant decline in the ability
Dual targeting to mitochondria and plastids of AtBT1 and ZmBT1, two members of the mitochondrial carrier family. Plant Cell Physiol
, 2011
"... AtBT1, respectively) are members of the mitochondrial car-rier family. Although they are presumed to be exclusively localized in the envelope membranes of plastids, confocal fluorescence microscopy analyses of potato, Arabidopsis and maize plants stably expressing green fluorescent protein (GFP) fus ..."
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AtBT1, respectively) are members of the mitochondrial car-rier family. Although they are presumed to be exclusively localized in the envelope membranes of plastids, confocal fluorescence microscopy analyses of potato, Arabidopsis and maize plants stably expressing green fluorescent protein (GFP
FORMULATION OF THE PROBLEM
"... Two well-known problems are the constructing of the evolutionary trees for a protein family and a family of species and the reconstructing of the molecular events taking place during evolution of a protein fam-ily [1–4]. Since a family of transcription factors evolves together with their binding sit ..."
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; the exact definition is given in the next section). Hence, part of the problem is identifying the edges corresponding to abrupt changes. These edges are termed (evolution-arily) significant and the set of edges is termed a car-rier of the evolutionary scenario. In addition to the carrier, the evolutionary
RESEARCH ARTICLE Cytokine, Antibody and Proliferative Cellular Responses Elicited by Taenia solium Calreticulin upon Experimental Infection in
, 1371
"... Taenia solium causes two diseases in humans, cysticercosis and taeniosis. Tapeworm car-riers are the main risk factor for neurocysticercosis. Limited information is available about the immune response elicited by the adult parasite, particularly the induction of Th2 re-sponses, frequently associated ..."
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Taenia solium causes two diseases in humans, cysticercosis and taeniosis. Tapeworm car-riers are the main risk factor for neurocysticercosis. Limited information is available about the immune response elicited by the adult parasite, particularly the induction of Th2 re-sponses, frequently
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