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Results 11 - 20
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1,293
Transmembrane topology of ceramide synthase in yeast
- Biochemical Journal
"... Ceramide plays a crucial role as a basic building block of sphingo-lipids, but also as a signalling molecule mediating cell-fate de-cisions. Three genes, LAG1, LAC1 and LIP1, have been shown to be required for ceramide synthase activity in Saccharomyces ..."
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Cited by 3 (2 self)
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Ceramide plays a crucial role as a basic building block of sphingo-lipids, but also as a signalling molecule mediating cell-fate de-cisions. Three genes, LAG1, LAC1 and LIP1, have been shown to be required for ceramide synthase activity in Saccharomyces
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
- J. Cell
, 2001
"... Abstract. The cargo that the molecular motor kinesin moves along microtubules has been elusive. We searched for binding partners of the COOH terminus of kinesin light chain, which contains tetratricopeptide repeat (TPR) motifs. Three proteins were found, the c-jun NH 2-terminal kinase (JNK)–interact ..."
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Cited by 83 (3 self)
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that kinesin carries the JIP scaffolds preloaded with cytoplasmic (dual leucine zipper– bearing kinase) and transmembrane signaling molecules (the Reelin receptor, ApoER2). These results demonstrate a direct interaction between conventional kinesin and a cargo, indicate that motor proteins are linked
Ankyrin-binding Proteins Related to Nervous System Cell Adhesion Molecules: Candidates to Provide Transmembrane and Intercellular Connections in Adult Brain
"... Abstract. A major class of ankyrin-binding glycoproteins have been identified in adult rat brain of 186, 155, and 140 kD that are alternatively spliced products of the same pre-mRNA. Characterization of cDNAs demonstrated that ankyrin-binding glycoproteins (ABGPs) share 72 % amino acid sequence iden ..."
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Cited by 21 (3 self)
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identity with chicken neurofascin, a membrane-spanning neural cell adhesion molecule in the Ig super-family expressed in embryonic brain. ABGP polypeptides have the following features consistent with a role as ankyrin-binding proteins in vitro and in vivo " (a) ABGPs and ankyrin associate as pure
Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro
- J. Cell
, 1989
"... Abstract. We have investigated two aspects of membrane traffic at early stages of endocytosis: membrane fusion and microtubule-dependent transport. As a marker, we have used the trans-membrane glycoprotein G of vesicular stomatitis virus implanted into the plasma membrane and then internalized for d ..."
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Cited by 125 (17 self)
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Abstract. We have investigated two aspects of membrane traffic at early stages of endocytosis: membrane fusion and microtubule-dependent transport. As a marker, we have used the trans-membrane glycoprotein G of vesicular stomatitis virus implanted into the plasma membrane and then internalized
Specificity of Transmembrane Protein Palmitoylation in Yeast
"... Many proteins are modified after their synthesis, by the addition of a lipid molecule to one or more cysteine residues, through a thioester bond. This modification is called S-acylation, and more commonly palmitoylation. This reaction is carried out by a family of enzymes, called palmitoyltransferas ..."
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Many proteins are modified after their synthesis, by the addition of a lipid molecule to one or more cysteine residues, through a thioester bond. This modification is called S-acylation, and more commonly palmitoylation. This reaction is carried out by a family of enzymes, called
Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
- EMBO J
, 1998
"... Selective degradation of proteins at the endoplasmic reticulum (ER-associated degradation) is thought to proceed largely via the cytosolic ubiquitin–proteasome pathway. Recent data have indicated that the disloca-tion of short-lived integral-membrane proteins to the cytosolic proteolytic system may ..."
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Cited by 40 (0 self)
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rapidly through the N-terminal cytosolic domain of the substrate, but slows down considerably when continued degradation of the molecule requires membrane extraction. Thus, proteasomes engaged in ER degradation can directly process transmembrane proteins through a mechanism in which the dislocation
Association between a Transmembrane Protein Tyrosine Phosphatase and the Cadherin-Catenin Complex
"... Abstract. Cadherins are calcium-dependent cell adhesion molecules that play fundamental roles in embryonic development, tissue morphogenesis, and cancer. A prerequisite for their function is association with the actin cytoskeleton via the catenins. Tyrosine phosphorylation of 13-catenin, which corre ..."
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Cited by 34 (2 self)
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Abstract. Cadherins are calcium-dependent cell adhesion molecules that play fundamental roles in embryonic development, tissue morphogenesis, and cancer. A prerequisite for their function is association with the actin cytoskeleton via the catenins. Tyrosine phosphorylation of 13-catenin, which
Methods for Transmembrane Protein Topology and Alpha Helix Prediction
, 2012
"... Alpha-helical transmembrane proteins are essential to many biological processes, such as transport, signaling, intracellular communication, cell recognition, and adhesion 1. These proteins also comprise the majority of drug targets. However, because experimentally determining the structures of these ..."
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Alpha-helical transmembrane proteins are essential to many biological processes, such as transport, signaling, intracellular communication, cell recognition, and adhesion 1. These proteins also comprise the majority of drug targets. However, because experimentally determining the structures
Location of a Constriction in the Lumen of a Transmembrane Pore by Targeted Covalent Attachment of Polymer Molecules
"... abstract Few methods exist for obtaining the internal dimensions of transmembrane pores for which 3-D structures are lacking or for showing that structures determined by crystallography reflect the internal dimensions of pores in lipid bilayers. Several approaches, involving polymer penetration and ..."
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Cited by 6 (2 self)
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abstract Few methods exist for obtaining the internal dimensions of transmembrane pores for which 3-D structures are lacking or for showing that structures determined by crystallography reflect the internal dimensions of pores in lipid bilayers. Several approaches, involving polymer penetration
Transmembrane biogenesis of the vesicular stomatitis virus glycoprotein
- J. Cell Biol
, 1979
"... Previous work has shown that the mRNA encoding the vesicular stomatitis virus (VSV) glycoprotein (G) is bound to the rough endoplasmic reticulum (RER) and that newly made G protein is localized to the RER. In this paper, we have investigated the topology and processing of the newly synthesized G pro ..."
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Cited by 4 (0 self)
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removes-5 % (30 amino acids) from each G molecule. These proteases will digest the entire G protein if detergents are present during digestion. Using the method of Dintzis (1961, Proc. Natl. Acad. Sci. U. S. A.,17:247-261) to order tryptic peptides (8), we show that peptides lost from G protein
Results 11 - 20
of
1,293
