How the immune system generates diversity: Pathogen space coverage with random and evolved antibody libraries

How the immune system generates diversity: Pathogen space coverage with random and evolved antibody libraries (1999)

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by Mihaela Oprea , Stephanie Forrest

Venue:	In GECCO 99, Real-world Applications Track
Citations:	14 - 2 self

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Datum	Value	Source
TITLE	How the immune system generates diversity: Pathogen space coverage with random and evolved antibody libraries	user correction - Legacy Corrections
AUTHOR NAME	Mihaela Oprea	user correction - Legacy Corrections
AUTHOR AFFIL	Dept. of Computer Science; University of New Mexico	user correction - Legacy Corrections
AUTHOR ADDR	Albuquerque, NM 87131-1386	user correction - Legacy Corrections
AUTHOR NAME	Stephanie Forrest	user correction - Legacy Corrections
AUTHOR AFFIL	Dept. of Computer Science; University of New Mexico	user correction - Legacy Corrections
AUTHOR ADDR	Albuquerque, NM 87131-1386	user correction - Legacy Corrections
ABSTRACT	The immune system uses many strategies to generate its enormous repertoire of diverse antibodies, but their relative importance is not understood. Here we address the contribution of antibody gene libraries to the antibody repertoire. We introduce a general framework, in which we can study many antibody-pathogen matching rules, including the widely-used shape-space model (Perelson and Oster, 1979). We use the genetic algorithm as a model of evolution to investigate the type of antibody repertoires that might evolve in relation to a given pathogenic environment. For the antibody/pathogen matching rules that we studied, the scaling relation between fitness and the size of the evolved antibody library is only a shifted variant of the scaling relation that we obtain with random libraries of the same size. We discuss how our results compare to the antibodies that are expressed in newborns, and we discuss the implications of our results for recent experiments with phage a...	user correction - Legacy Corrections
YEAR	1999	INFERENCE
VENUE	In GECCO 99, Real-world Applications Track	INFERENCE
VENUE TYPE	CONFERENCE	INFERENCE
PAGES	1651--1656	INFERENCE
VOLUME	2	INFERENCE
CITATIONS	14 found	ParsCit 1.0