A `sticky' interhemispheric switch in bipolar disorder?

A `sticky' interhemispheric switch in bipolar disorder? (1998)

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by John D. Pettigrew , Steven M. Miller

Venue:	NEUROSCI. ABSTR
Citations:	6 - 2 self

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Datum	Value	Source
TITLE	A `sticky ' interhemispheric switch in bipolar disorder?	SVM HeaderParse 0.2
AUTHOR NAME	John D. Pettigrew	SVM HeaderParse 0.2
AUTHOR AFFIL	Vision,Touch and Hearing Research Centre, University of Queensland	SVM HeaderParse 0.2
AUTHOR ADDR	St Lucia, Brisbane 4072, Australia	SVM HeaderParse 0.2
AUTHOR NAME	Steven M. Miller	SVM HeaderParse 0.2
AUTHOR AFFIL	Vision,Touch and Hearing Research Centre, University of Queensland	SVM HeaderParse 0.2
AUTHOR ADDR	St Lucia, Brisbane 4072, Australia	SVM HeaderParse 0.2
ABSTRACT	Despite years of research into bipolar disorder (manic depression), its underlying pathophysiology remains elusive. It is widely acknowledged that the disorder is strongly heritable, but the genetics are complex with less than full concordance in monozygotic twins and at least four susceptibility loci identi-¢ed. We propose that bipolar disorder is the result of a genetic propensity for slow interhemispheric switching mechanisms that become `stuck ' in one or the other state. Because slow switches are also `sticky' when compared with fast switches, the clinical manifestations of bipolar disorder may be explained by hemispheric activation being `stuck ' on the left (mania) or on the right (depression). Support for this `sticky ' interhemispheric switching hypothesis stems from our recent observation that the rate of perceptual alternation in binocular rivalry is slow in euthymic subjects with bipolar disorder (nˆ18, medianˆ0.27 Hz) compared with normal controls (nˆ49, medianˆ0.60 Hz, p50.0005). We have presented evidence elsewhere that binocular rivalry is itself an interhemispheric switching phenomenon. The rivalry alternation rate (putative interhemispheric switch rate) is robust in a given individual, with a test^retest correlation of more than 0.8, making it suitable for genetic studies. The interhemispheric switch rate may provide a trait-dependent biological marker for bipolar disorder.	SVM HeaderParse 0.2
CITATIONS	58 found	ParsCit 1.0