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Cerebral Cortex Advance Access published October 20, 2006 Mapping Cortical Thickness in Children with 22q11.2 Deletions
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@MISC{_cerebralcortex,
author = {},
title = {Cerebral Cortex Advance Access published October 20, 2006 Mapping Cortical Thickness in Children with 22q11.2 Deletions},
year = {}
}
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Abstract
22q11.2DS) involves cardiac and craniofacial anomalies, marked deficits in visuospatial cognition, and elevated rates of psychosis. Although the mechanism is unknown, characteristic brain alterations may predispose to development of psychosis and cognitive deficits in 22q11DS. We applied cortical pattern matching and new methods for measuring cortical thickness in millimeters to structural magnetic resonance images of 21 children with confirmed 22q11.2 deletions and 13 demographically matched healthy comparison subjects. Thickness was mapped at 65 536 homologous points, based on 3-dimensional distance from the cortical gray--white matter interface to the external gray--cerebrospinal fluid boundary. A pattern of regionally specific cortical thinning was observed in superior parietal cortices and right parietooccipital cortex, regions critical for visuospatial processing, and bilaterally in the most inferior portion of the inferior frontal gyrus (pars orbitalis), a key area for language
Keyphrases
mapping cortical thickness cerebral cortex advance access new method visuospatial cognition structural magnetic resonance image specific cortical thinning external gray cerebrospinal fluid boundary superior parietal cortex craniofacial anomaly cortical gray white matter interface homologous point key area 3-dimensional distance healthy comparison subject inferior portion visuospatial processing cortical pattern inferior frontal gyrus characteristic brain alteration right parietooccipital cortex cognitive deficit cortical thickness
