Fitting Genetic Models Using Markov Chain Monte Carlo Algorithms with Bugs." Twin Research and Human Genetics 9 (2006)
| Citations: | 4 - 2 self |
BibTeX
@MISC{Bugs06fittinggenetic,
author = {Algorithms Bugs and Stéphanie M. Van Den Berg and Leo Beem and Dorret I. Boomsma},
title = {Fitting Genetic Models Using Markov Chain Monte Carlo Algorithms with Bugs." Twin Research and Human Genetics 9},
year = {2006}
}
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Abstract
Maximum likelihood estimation techniques are widely used in twin and family studies, but soon reach computational boundaries when applied to highly complex models (e.g., models including geneby-environment interaction and gene–environment correlation, item response theory measurement models, repeated measures, longitudinal structures, extended pedigrees). Markov Chain Monte Carlo (MCMC) algorithms are very well suited to fit complex models with hierarchically structured data. This article introduces the key concepts of Bayesian inference and MCMC parameter estimation and provides a number of scripts describing relatively simple models to be estimated by the freely obtainable BUGS software. In addition, inference using BUGS is illustrated using a
