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Interactive Visualization – a Key Prerequisite for Reconstruction and Analysis of Anatomically Realistic Neural Networks
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BibTeX
@MISC{Dercksen_interactivevisualization,
author = {Vincent J. Dercksen and Marcel Oberlaender and Bert Sakmann and Hans-christian Hege and M. Oberlaender and B. Sakmann},
title = {Interactive Visualization – a Key Prerequisite for Reconstruction and Analysis of Anatomically Realistic Neural Networks},
year = {}
}
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Abstract
Abstract Recent progress in large-volume microscopy, tissue-staining, as well as in image processing methods and 3D anatomy reconstruction allow neuroscientists to extract previously inaccessible anatomical data with high precision. For instance, determination of neuron numbers, 3D distributions and 3D axonal and dendritic branching patterns support recently started efforts to reconstruct anatomically real-istic network models of many thousand neurons. Such models aid in understanding neural network structure, and, by numerically simulating electro-physiological sig-naling, also to reveal their function. We illustrate the impact of visual computing on neurobiology at the example of important steps that are required for the reconstruction of large neural networks. In our case, the network to be reconstructed represents a single cortical column in the rat brain, which processes sensory information from its associated facial whisker hair. We demonstrate how analysis and reconstruction tasks, such as neuron somata counting and tracing of neuronal branches, have been incrementally accelerated – finally leading to efficiency gains of orders of magnitude. We also show how steps
Keyphrases
key prerequisite anatomically realistic neural network interactive visualization image processing method neuronal branch real-istic network model rat brain single cortical column inaccessible anatomical data anatomy reconstruction allow neuroscientist large neural network neuron number electro-physiological sig-naling sensory information abstract recent progress important step high precision facial whisker hair neuron soma counting reconstruction task dendritic branching pattern support neural network structure large-volume microscopy
