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SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVES
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BibTeX
@MISC{Venkatesh_synthesis,characterisation,
author = {P. Venkatesh and S. N. Pandeya},
title = {SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVES},
year = {}
}
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Abstract
ABSTRACT: A series of some novel 2-amino benzothiazole derivatives were synthesized and evaluated for anti-inflammatory activity. The titled compounds were synthesized from the substituted aromatic amines through the intermediate substituted 1-phenylthiourea oxidation by bromine water in acidic medium. The purity of the synthesized compounds were judged by their C, H and N analysis and the structure was analyzed on the basis of IR, 1HNMR and Mass spectral data. The anti-inflammatory activities of new compounds were determined by λ-Carrageenan-induced mice paw edema method using diclofenac sodium as a standard. Among the compounds tested three compounds Bt2 (5-chloro-1,3-benzothiazole-2-amine), Bt (6-methoxy-1,3-benzothiazole-2-amine) and Bt7 (6-methoxy-1,3-benzothiazole-2-amine)were the most active compounds in these series when compared with diclofenac sodium. In the SAR study, the phenyl ring substituted with chloro at 5 position, methoxy substitution at 4 and 6-position in benzothiazole ring system showed better anti-inflammatory activity. Key Words: Anti-inflammatory, bromine water, hind paw edema, benzothiazoles
Keyphrases
characterisation anti-inflammatory activity 2-amino benzothiazole derivative anti-inflammatory activity diclofenac sodium bromine water compound bt2 titled compound phenyl ring synthesized compound new compound aromatic amine novel 2-amino benzothiazole derivative carrageenan-induced mouse paw edema method methoxy substitution hind paw edema sar study benzothiazole ring system active compound key word mass spectral data acidic medium 1-phenylthiourea oxidation
