A Simple Method to Predict Protein Binding From Aligned Sequences (2005)
BibTeX
@MISC{Mhc05asimple,
author = {Application To Mhc and Elodie Duprat and Marie-paule Lefranc and Olivier Gascuel},
title = {A Simple Method to Predict Protein Binding From Aligned Sequences},
year = {2005}
}
OpenURL
Abstract
Motivation: The MHC superfamily (MhcSF) consists of immune system MHC class I (MHC-I) proteins, along with proteins with a MHC-I-like structure that are involved in a large variety of biological processes. Beta2-microglobulin (B2M) noncovalent binding to MHCI proteins is required for their surface expression and function, while MHC-I-like proteins interact, or not, with B2M. This study was designed to predict B2M binding (or non-binding) of newly identified MhcSF proteins, in order to decipher their function, understand the molecular recognition mechanisms, and identify deleterious mutations. IMGT standardization of MhcSF protein domains provides a unique numbering of the multiple alignment positions, and conditions to develop such predictive tool.







