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Prochloraz Inhibits Testosterone Production at Dosages below Those that Affect Androgen-Dependent Organ Weights or the Onset of Puberty in the Male Sprague Dawley Rat (2007)
BibTeX
@MISC{07prochlorazinhibits,
author = {},
title = {Prochloraz Inhibits Testosterone Production at Dosages below Those that Affect Androgen-Dependent Organ Weights or the Onset of Puberty in the Male Sprague Dawley Rat},
year = {2007}
}
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Abstract
Prochloraz (PCZ) is an imidazole fungicide that inhibits gonadal steroidogenesis and antagonizes the androgen receptor (AR). We hypothesized that pubertal exposure to PCZ would reduce testosterone production and delay male rat reproductive development. Sprague Dawley rats were dosed by gavage with 0, 31.3, 62.5, or 125 mg/kg/day of PCZ from postnatal day (PND) 23 to 42 or 51. There was a significant delay in preputial separation (PPS) at 125 mg/kg/day PCZ and several of the androgen-dependent organ weights were decreased significantly, but the significant organ weight effects were not consistent between the 2 necropsies (PND 42 vs. 51). At both ages, serum testosterone levels and ex vivo testosterone release from the testis were significantly decreased whereas serum progesterone and 17a-hydroxyproges-terone levels were significantly increased at dose levels below those that affected PPS or reproductive organ weights. The
Keyphrases
androgen-dependent organ weight male sprague dawley rat prochloraz inhibits testosterone production gonadal steroidogenesis testosterone release androgen receptor dose level mg kg day pcz postnatal day imidazole fungicide sprague dawley rat testosterone level significant organ weight effect testosterone production significant delay reproductive development pubertal exposure preputial separation reproductive organ weight mg kg day 17a-hydroxyproges-terone level
