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What"-Then-"Where" in visual working memory: an event-related fMRI study (1999)
| Venue: | Journal of Cognitive Neuroscience |
| Citations: | 49 - 4 self |
BibTeX
@ARTICLE{Postle99what"-then-"where"in,
author = {Bradley R. Postle},
title = {What"-Then-"Where" in visual working memory: an event-related fMRI study},
journal = {Journal of Cognitive Neuroscience},
year = {1999}
}
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Abstract
Behavioral studies indicate that spatial and object working memory are computed by dissociable subsystems. We investi-gated the neural bases of this dissociation with a whole-brain fMRI design and analysis technique that permitted direct as-sessment of delay-period activity, uncontaminated by other components of the trial. The task employed a “what”-then-“where ” design, with an object and a spatial delay period incorporated in each trial; within-trial order of delay conditions was balanced across each scan. Our experiment failed to ªnd evidence, at the single-subject level and at the group level, for anatomical segregation of spatial and object working memory function in the frontal cortex. Delay-period activity in the caudate nucleus revealed a sensitivity to position in the trial in the spatial, but not the object, condition. In posterior regions, spatial delay-period activity was associated with preferential recruitment of extrastriate areas falling within Brodmann’s area 19 and, less reliably, the superior parietal lobule. Object-speciªc delay-period activity was found predominantly in ventral re-gions of the posterior cortex and demonstrated more topo-graphic variability across subjects than did spatial working memory activity.
Keyphrases
event-related fmri study visual working memory delay-period activity within-trial order memory function extrastriate area neural base delay condition object-speci delay-period activity analysis technique posterior region posterior cortex behavioral study frontal cortex anatomical segregation superior parietal lobule dissociable subsystem whole-brain fmri design topo-graphic variability spatial delay period caudate nucleus ventral re-gions spatial delay-period activity direct as-sessment preferential recruitment group level single-subject level memory activity
