Blocking Gibbs Sampling for Linkage Analysis in Large Pedigrees with Many Loops (1996)
| Venue: | AMERICAN JOURNAL OF HUMAN GENETICS |
| Citations: | 17 - 1 self |
BibTeX
@TECHREPORT{Jensen96blockinggibbs,
author = {Claus Skaanning Jensen and Augustine Kong},
title = {Blocking Gibbs Sampling for Linkage Analysis in Large Pedigrees with Many Loops},
institution = {AMERICAN JOURNAL OF HUMAN GENETICS},
year = {1996}
}
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Abstract
We will apply the method of blocking Gibbs sampling to a problem of great importance and complexity -- linkage analysis. Blocking Gibbs combines exact local computations with Gibbs sampling in a way that complements the strengths of both. The method is able to handle problems with very high complexity such as linkage analysis in large pedigrees with many loops; a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem.
