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Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise (2004)
| Venue: | Medicine & Science in Sports & Exercise |
| Citations: | 9 - 3 self |
BibTeX
@INPROCEEDINGS{Tipton04ingestionof,
author = {Kevin D. Tipton and Tabatha A. Elliott and Melanie G. Cree and Steven E. Wolf and Arthur P. Sanford and Robert R. Wolfe},
title = {Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise},
booktitle = {Medicine & Science in Sports & Exercise},
year = {2004},
pages = {2073--2081}
}
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Abstract
Purpose: Determination of the anabolic response to exercise and nutrition is important for individuals who may benefit from increased muscle mass. Intake of free amino acids after resistance exercise stimulates net muscle protein synthesis. The response of muscle protein balance to intact protein ingestion after exercise has not been studied. This study was designed to examine the acute response of muscle protein balance to ingestion of two different intact proteins after resistance exercise. Methods: Healthy volunteers were randomly assigned to one of three groups. Each group consumed one of three drinks: placebo (PL; N 7), 20 g of casein (CS; N 7), or whey proteins (WH; N 9). Volunteers consumed the drink 1 h after the conclusion of a leg extension exercise bout. Leucine and phenylalanine concentrations were measured in femoral arteriovenous samples to determine balance across the leg. Results: Arterial amino acid concentrations were elevated by protein ingestion, but the pattern of appearance was different for CS and WH. Net amino acid balance switched from negative to positive after ingestion of both proteins. Peak leucine net balance over time was greater for WH (347 50 nmol·min1·100 mL1 leg) than CS (133 45 nmol·min1·100 mL1 leg), but peak phenylalanine balance was similar for CS and WH. Ingestion of both CS and WH stimulated a significantly larger net phenylalanine uptake after resistance exercise, compared with the PL (PL5 15 mg, CS 84 10 mg, WH 62 18 mg). Amino acid uptake relative to amount ingested was similar
Keyphrases
resistance exercise whey protein muscle anabolism nmol min1 ml1 leg muscle protein balance protein ingestion peak phenylalanine balance net muscle protein synthesis phenylalanine concentration free amino acid leg extension exercise bout peak leucine net balance net amino acid balance healthy volunteer arterial amino acid concentration anabolic response acute response different intact protein femoral arteriovenous sample amino acid uptake relative increased muscle mass net phenylalanine uptake
