DMCA
Vancomycin MIC creep in non- vancomycin-intermediate Staphylococcus aureus (VISA), vancomycinsusceptible clinical methicillin-resistant S. aureus (MRSA) blood isolates from 2001-05
| Venue: | J Antimicrob Chemother |
| Citations: | 60 - 0 self |
BibTeX
@ARTICLE{Steinkraus_vancomycinmic,
author = {Gregory Steinkraus and Roger White and Lawrence Friedrich},
title = {Vancomycin MIC creep in non- vancomycin-intermediate Staphylococcus aureus (VISA), vancomycinsusceptible clinical methicillin-resistant S. aureus (MRSA) blood isolates from 2001-05},
journal = {J Antimicrob Chemother},
year = {},
pages = {60--788}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
shifts (MIC creep) at a tertiary care institution occurred that may have gone undetected using traditional susceptibility markers (percentage susceptible, MIC50, MIC90) over a 5 year period. Additionally, MIC trends were evaluated for oxacillin, linezolid and daptomycin. Methods: Etest MICs were performed on MRSA blood culture isolates (January 2001–December 2005). Only one isolate per patient was studied. The reported Etest MIC result was used and not rounded upward. MIC50, MIC90, median and geometric mean MIC, percentage susceptible and percentage resist-ant were calculated for each drug in each year. Non-parametric methods (linear correlation and Mantel–Haenszel x2) were used to assess MIC trends over time and the association of vancomycin, linezolid and daptomycin MICs with oxacillin MICs. Results: All isolates were susceptible to vancomycin, linezolid and daptomycin and resistant to oxacil-lin. MICs increased for vancomycin, linezolid and oxacillin (P < 0.0001); however, daptomycin MICs decreased slightly (P 5 0.0386). For vancomycin, linezolid and oxacillin, there were significant increases (P < 0.0001) in the percentage of isolates with MICs that were higher than the respective 2001 median MIC, but not for daptomycin (P 5 0.1361). Oxacillin MICs were associated with MICs of
Keyphrases
vancomycin mic creep vancomycinsusceptible clinical methicillin-resistant blood isolates non vancomycin-intermediate staphylococcus aureus mic trend daptomycin mics mrsa blood culture tertiary care institution mic creep oxacillin mics geometric mean mic etest mic result significant increase traditional susceptibility marker median mic linear correlation percentage resist-ant mantel haenszel x2 year period non-parametric method percentage susceptible
