Abstract

A new two-stage approach for nonlinear brain image registration is proposed. In the first stage, an active contour algorithm is used to establish a homothetic one-to-one map between a set of region boundaries in two images to be registered. This mapping is used in the second step: a two-dimensional transformation which is based on an elastic body deformation. This method is tested by registering magnetic resonance images to atlas images. I. Introduction Registration of both intra-subject and inter-subject brain images has been the subject of extensive study in the medical imaging literature. The various techniques that have been proposed can be classified into three major categories: polynomial transformations, similarity-based methods, and boundary-based methods. Polynomial transformations [1, 2, 3] apply a polynomial warping and determine the coefficients of the polynomial using linear regression if a sufficient number of landmark points is provided. Numerical instabilities and the ...

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