DMCA
Genetic plasticity of V genes under somatic hypermutation: Statistical analyses using a new resampling-based methodology. (1999)
| Citations: | 6 - 1 self |
BibTeX
@MISC{Oprea99geneticplasticity,
author = {Mihaela Oprea and Thomas B. Kepler},
title = {Genetic plasticity of V genes under somatic hypermutation: Statistical analyses using a new resampling-based methodology.},
year = {1999}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Evidence for somatic hypermutation of immunoglobulin genes has been observed in all the species in which immunoglobulins have been found. Previous studies have suggested that codon usage in Ig V genes is such that the sequence-specificity of somatic hypermutation results in greater mutability in complementarity-determining regions of the gene than in the framework regions. We have developed a new resampling-based methodology to explore genetic plasticity in individual V genes and in V gene families in a statistically meaningful way. We determine what factors contribute to this mutability difference, and characterize the strength of selection for this effect. We nd that although the codon usage in Ig V genes renders them distinct among translationally equivalent sequences with random codon usage, they are nevertheless far from being optimal in this regard. We find that the mutability patterns in a number of species are similar to those we find for human sequences. Interestingly, sheep seque...
Keyphrases
genetic plasticity somatic hypermutation new resampling-based methodology statistical analysis codon usage complementarity-determining region meaningful way immunoglobulin gene previous study ig gene render human sequence random codon usage ig gene individual gene mutability difference framework region somatic hypermutation result equivalent sequence sheep seque gene family
