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Printed In Great Britain Influence of Gender on Susceptibility to Multiple Sclerosis and Age of Onset in Concordant Sibships
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@MISC{Warren_printedin,
author = {Sharon A Warren and K G Warren},
title = {Printed In Great Britain Influence of Gender on Susceptibility to Multiple Sclerosis and Age of Onset in Concordant Sibships},
year = {}
}
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Abstract
Canada) and Warren K G. Influence of gender on susceptibility to multiple sclerosis and age of onset in concordant sib-ships. International Journal of Epidemiology 199Q; 25: 142-145. Background. Research has produced conflicting findings about whether there is an excess of like-sexed pairs among concordant multiple sclerosis (MS) sibships. Although a positive correlation in onset age among sibling pairs overall has been reported, no data have been published describing age at onset correlations for like-sexed versus unlike-sexed pairs. The purpose of this study was to provide additional information on both issues. Methods. Patients with an MS sibling were sought through the files of the University of Alberta MS Clinic (Edmonton, Canada). The clinic neurologist either reviewed clinical/autopsy material or assessed relatives of index cases prior to ac-cepting the relative as having MS. Pairs of siblings (excluding twins) were divided into (1) male-male pairs, (2) female-female pairs, and (3) female-male pairs. Results. A total of 62 concordant sibling pairs were identified. There were 33 like-sexed pairs (6 male-male/27 female-female) and 29 unlike-sexed pairs. The observed number of like-sexed pairs was not significantly different from the ex-pected frequency using 2 x 2 x2 analysis, where expected values represent the binomial distribution predicted from the frequency of each sex as determined by total number of males and females. The age at onset intraclass correlation coefficient was-0.09 for sibling pairs overall,-0.22 for like-sexed pairs and +0.02 for unlike-sexed pairs. Conclusions. This study does not provide evidence for an association between disease susceptibility and gender in sib-lings concordant for MS; nor does it suggest that genetics plays a role in onset age.
Keyphrases
like-sexed pair great britain influence concordant sibships multiple sclerosis onset age unlike-sexed pair onset intraclass correlation coefficient was-0 conflicting finding additional information clinic neurologist female-male pair clinical autopsy material male-male pair concordant sib-ships positive correlation assessed relative international journal onset correlation x2 analysis total number alberta m clinic female-female pair binomial distribution observed number index case sib-lings concordant m sibling like-sexed versus unlike-sexed pair ex-pected frequency disease susceptibility concordant multiple sclerosis
