Abstract

A new two-stage approach for brain image registration is proposed. In the first stage, an active contour algorithm is used to establish a length-preserving, one-to-one mapping between the cortical and the ventricular boundaries in the two images to be registered. This mapping is used in the second step by a two-dimensional transformation which is based on an elastic body deformation. This method was tested by registering magnetic resonance images to both photographic pathology images and atlas images. I. Introduction Registration of both intra-subject and inter-subject images has been the subject of extensive study in the medical imaging literature. It is important for several reasons. First, images obtained through different modalities can be properly superposed only after accurate registration. Visualization and quantitative analysis can be improved by such superposition. Second, atlas images accurately registered to patient data can be used for automatic identification of brain an...

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