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Evolutionary rate in the protein interaction network
| Venue: | Science |
| Citations: | 98 - 0 self |
BibTeX
@ARTICLE{Fraser_evolutionaryrate,
author = {Hunter B. Fraser and Aaron E. Hirsh and Lars M. Steinmetz and Curt Scharfe and Marcus W. Feldman},
title = {Evolutionary rate in the protein interaction network},
journal = {Science},
year = {},
pages = {2002}
}
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Abstract
High-throughput screens have begun to reveal the protein interaction network that underpins most cellular functions in the yeast Saccharomyces cerevisiae. How the organization of this network affects the evolution of the proteins that compose it is a fundamental question in molecular evolution. We show that the connectivity of well-conserved proteins in the network is negatively correlated with their rate of evolution. Proteins with more interactors evolve more slowly not because they are more important to the organism, but because a greater proportion of the protein is directly involved in its function. At sites important for interaction between proteins, evolutionary changes may occur largely by coevolution, in which substitutions in one protein result in selection pressure for reciprocal changes in interacting partners. We conÞrm one predicted out-come of this processÑnamely, that interacting proteins evolve at similar rates. A protein’s rate of evolution is thought to depend both on its dispensability to the or-ganism and on the proportion of potential
