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A study of analysis parameters that influence the sensitivity of event-related fMRI analyses (2000)
| Venue: | NeuroImage |
| Citations: | 11 - 0 self |
BibTeX
@ARTICLE{Hopfinger00astudy,
author = {Joseph B. Hopfinger and Christian Büchel and Andrew P. Holmes and Karl J. Friston},
title = {A study of analysis parameters that influence the sensitivity of event-related fMRI analyses},
journal = {NeuroImage},
year = {2000},
pages = {326--333}
}
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Abstract
To assess the effect of various analysis parameters on the sensitivity of event-related fMRI analyses, 36 analyses were performed on a single fMRI data-set, varying parameters along four axes: (1) resampled voxel size; (2) spatial smoothing; (3) temporal smoothing; and (4) the set of basis functions used to model event-related responses. Sensitivity (i.e., the probability of detecting an activation given it exists) was assessed in terms of Z scores and by a metric for corrected P values, the negative log of the expected Euler characteristic. Sixteen brain regions distributed across cortical and subcortical areas were included in the meta-analysis. Main effects on sensitivity were found for resampled voxel size, spatial smoothing, temporal smoothing, and the set of basis functions chosen. The analysis parameters that generally produced the most sensitive analyses were a 2-mm3 resampled voxel size, 10-mm spatial smoothing, 4-s temporal smoothing, and a basis set comprising a hemodynamic response function and its temporal derivative. � 2000 Academic Press
Keyphrases
analysis parameter event-related fmri analysis temporal smoothing spatial smoothing basis function 2-mm3 resampled voxel size sixteen brain region 4-s temporal smoothing 10-mm spatial smoothing temporal derivative main effect subcortical area single fmri data-set voxel size resampled voxel size hemodynamic response function various analysis parameter negative log sensitive analysis event-related response academic press
