DMCA
Microcapsule, Scanning Electron Microscope, Emulsion Solvent Evaporation Technique Correspondence to Author:
BibTeX
@MISC{Sium-ul_microcapsule,scanning,
author = {Md. Sium-ul and Hossain Miah and Md. Asraful Islam and A Saha and Md. Mehedi Faysal and Md. Sium-ul and Hossain Miah},
title = {Microcapsule, Scanning Electron Microscope, Emulsion Solvent Evaporation Technique Correspondence to Author:},
year = {}
}
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Abstract
ABSTRACT: Sustained released Aceclofenac microcapsules based on synthetic hydrophilic polymer hydroxypropyl methylcellulose (HPMC) were developed in this study in an attempt to design a dosage form that would manifest desirable release profile. W/O emulsion solvent evaporation technique was employed. Various release retarding agents were used to provide the analgesic and antiinflammatory action of aceclofenac for prolong period of time. Microcapsules were prepared at a fixed stirring rate of 1000 rpm. Polymeric solution containing aceclofenac was emulsified by light liquid paraffin (LLP) which was initially emulsified by 1 % (w/w of the continuum) lipophilic surfactant Span 80. The formulated microcapsules were evaluated for drug-polymer drug loading efficiency, micromeritic properties, surface morphology study, in-vitro drug release kinetics. It was found that all formulations showed satisfactory flow behavior. The maximum loading efficiency of was found to be 87.42%. SEM study showed that the microcapsules were discrete and spherical shaped. Efficacy of the dosage forms were evaluated in terms of in-vitro dissolution studies which showed statistically significant difference among the drug release profile from different polymeric blend as well as their increasing concentration. However, by increasing the polymer concentration, the rate of drug release from the microcapsules decreases dramatically. Drug release from all formulations followed Korsemeyer-Peppas kinetics and release mechanisms followed non-Fickian or anomalous type release.
Keyphrases
emulsion solvent evaporation technique correspondence scanning electron microscope dosage form drug release significant difference lipophilic surfactant span synthetic hydrophilic polymer hydroxypropyl methylcellulose polymeric solution spherical shaped antiinflammatory action desirable release profile aceclofenac microcapsules satisfactory flow behavior sem study anomalous type release in-vitro drug release kinetics surface morphology study light liquid paraffin prolong period micromeritic property different polymeric blend in-vitro dissolution study maximum loading efficiency polymer concentration release mechanism drug release profile emulsion solvent evaporation technique formulated microcapsules korsemeyer-peppas kinetics drug-polymer drug loading efficiency various release
