How the immune system generates diversity: Pathogen space coverage with random and evolved antibody libraries (1999)
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| Venue: | In GECCO 99, Real-world Applications Track |
| Citations: | 19 - 2 self |
BibTeX
@INPROCEEDINGS{Oprea99howthe,
author = {Mihaela Oprea and Stephanie Forrest},
title = {How the immune system generates diversity: Pathogen space coverage with random and evolved antibody libraries},
booktitle = {In GECCO 99, Real-world Applications Track},
year = {1999},
pages = {1651--1656},
publisher = {Press}
}
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Abstract
The immune system uses many strategies to generate its enormous repertoire of diverse antibodies, but their relative importance is not understood. Here we address the contribution of antibody gene libraries to the antibody repertoire. We introduce a general framework, in which we can study many antibody-pathogen matching rules, including the widely-used shape-space model (Perelson and Oster, 1979). We use the genetic algorithm as a model of evolution to investigate the type of antibody repertoires that might evolve in relation to a given pathogenic environment. For the antibody/pathogen matching rules that we studied, the scaling relation between fitness and the size of the evolved antibody library is only a shifted variant of the scaling relation that we obtain with random libraries of the same size. We discuss how our results compare to the antibodies that are expressed in newborns, and we discuss the implications of our results for recent experiments with phage a...
Keyphrases
antibody library immune system pathogen space coverage antibody repertoire diverse antibody general framework many antibody-pathogen matching rule genetic algorithm antibody gene library scaling relation widely-used shape-space model antibody pathogen many strategy pathogenic environment relative importance recent experiment enormous repertoire random library shifted variant
