Gestational Age
BibTeX
@MISC{Children_gestationalage,
author = {Prepubertal Children and Born Large and Anna S. Challa and Vasileios K. Cholevas and Georgios A. Vartholomatos and Ekaterini C. Siomou and Nikolaos I. Kolaitis and Eleni T. Bairaktari and Styliani K. Andronikou},
title = {Gestational Age},
year = {}
}
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OpenURL
Abstract
OBJECTIVE — To evaluate metabolic syndrome and cardiovascular disease risk factors in prepubertal children born large for gestational age (LGA) to nondiabetic, nonobese mothers. RESEARCH DESIGN AND METHODS — At 6–7 years of age, the comparison of various factors was made between 31 LGA and 34 appropriate-for-gestational-age (AGA) children: fibrinogen, antithrombin III, protein C and S, fasting insulin, glucose, homeostasis assessment model of insulin resistance (HOMA-IR) index, adiponectin, leptin, visfatin, IGF-1, IGF-binding protein (IGFBP)-1, IGFBP-3, lipids, and the genetic factors V Leiden G1691A mutation, prothrombin 20210A/G polymorphism, and mutation in the enzyme 5,10-methylenetetrahydrofolate-reductase gene (MTHFR-C677T). RESULTS — LGA children had higher levels of leptin (P � 0.01), fasting insulin (P � 0.01), and HOMA-IR (P � 0.01), but lower IGFBP-3 (P � 0.0001), fibrinogen (P � 0.0001), and lipoprotein(a) (P � 0.001) than AGA children. Significantly more LGA children were homozygous for the MTHFR-C677T mutation (P � 0.0016). CONCLUSIONS — Being born LGA to nondiabetic, nonobese mothers is associated with diverse effects on cardiometabolic risk factors at prepuberty.
Keyphrases
gestational age nonobese mother diverse effect homeostasis assessment model lga child insulin resistance cardiometabolic risk factor various factor 10-methylenetetrahydrofolate-reductase gene igf-binding protein antithrombin iii result lga child aga child cardiovascular disease risk factor genetic factor leiden g1691a mutation prepubertal child research design method mthfr-c677t mutation metabolic syndrome
