BibTeX
@MISC{Schuster96landscapesand,
author = {Peter Schuster},
title = {Landscapes And Molecular Evolution},
year = {1996}
}
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Abstract
that allows to choose the direction for the next step at random from all directions along which fitness does not decrease. Stationary states of populations correspond to local optima of the fitness landscape. Evolution is seen as a series of transitions between optima with increasing fitness values. Wright's metaphor saw a recent revival when sufficiently simple models of fitness landscapes became available [1, 41]. These models are based on spin glass theory [63, 66] or closely related to it like Kauffman's Nk model [42]. Evolution of RNA molecules has been studied by more realistic models that deal explicitly with molecular structures obtained from folding RNA sequences [23, 24]. Fitness values serving as input parameters for evolutionary dynamics were derived through evaluation of the structures. The complexity of RNA fitness landscapes originates from conflicting consequences of structural changes that are reminiscent of "frustration" in the theory of spin glasses [2]. Fitness in t
